INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
I-tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
Okokuqala, ikhonkco lecala le-semaglutide liyilwe ngokukodwa kwaye lisebenza ngokufanelekileyo, lidlala indima ebalulekileyo kwizicelo zayo zamayeza.Le khonkco yecala, efakwe kwi-26th ye-lysine i-residu ye-peptide chain, ayigcini nje ukunyusa ukuzinza kwesakhiwo se-semaglutide kodwa iququzelele ukusebenzisana kwayo kunye neemolekyuli ezithile ze-biological.
Okwesibini, ikhonkco lecala liquka i-18-carbon fatty diacid chain, eyenziwa ngokudibanisa kwe-glutamic acid, iimolekyuli ezimbini ze-8-amino-3,6-dioxaoctanoic acid (AEEA), kunye ne-octadecanedioic acid.Olu lwakhiwo olukhethekileyo lwekhonkco lwecala lonyusa ubudlelwane be-semaglutide kwi-albumin, ukunciphisa ukucocwa kwezintso kunye nokwandisa isiqingatha sobomi emzimbeni.Lo msebenzi wexesha elide wonyusa isiphumo sonyango kunye nokuqina kwechiza.
Ngaphezu koko, i-pegylation ye-chain chain iphakamisa ukunyibilika kwe-semaglutide kunye nokuhamba, ukunciphisa ukuhluzwa kweentso kunye nokuchithwa kweproteolytic.Olu hlengahlengiso lukwanciphisa i-pyrogenicity yechiza kwaye likhusela ekuhlaselweni kwe-immune system, ukuphucula ukuhanjiswa kweziyobisi kunye nokugcinwa kwindawo ekujoliswe kuyo.
Fmoc-AEEA-OH | Fmoc-AEEA-AEEA-OH | H-Glu-OtBU | I-Boc-Glu-Otbu(Osu) |
Fmoc-L-Ser(tBu)-OH | Fmoc-L-Lys-OH·HCl |
1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokubunjwa, inokwenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.