INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
I-FMOC-OT-BUTYL-D-TYROSINE;
I-FMOC-O-TERT-BUTYL-D-TYROSINE;
FMOC-D-TYR(TBU)-OH99%;
I-N-α-Fmoc-O-tert-butyl-D-tyrosine;
I-NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-D-tyrosine;
I-9-fluorenylmethyloxycarbonyl-D-tyrosine(tert-butyl)-OH;
(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoicacid;
I-Fmoc-D-Tyr(tBu)-OH(Fmoc-O-tert-butyl-D-tyrosine)
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ukukugcina kulungile ukufika kwindawo oya kuyo.Siya kutywina iibhotile zeplastiki ngeteyiphu yeplastiki emhlophe kwindawo yesikhewu seziciko.
Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.Siza kuwela iteyiphu yeplastiki ngaphandle ukulungisa yonke indawo.Kwaye ukuba kuyimfuneko, siya kubadlwengula ngefilimu elula ngaphandle.
I-Fmoc-D-Tyr (tBu) -OH, eyaziwa ngokuba yi-Fmoc-O-tert-butyl-D-tyrosine, i-amino acid derivative eguqulweyo eneempawu ezizodwa zeekhemikhali.Ifumana izicelo kwi-biochemistry, ukufunyanwa kweziyobisi, i-peptide synthesis, kunye ne-organic synthesis.
Uphando lweBiyochemical:
I-Fmoc-D-Tyr (tBu) -OH ingasetyenziselwa ukufunda isakhiwo seprotheni kunye nomsebenzi.Ngenxa yokwakheka kweekhemikhali ezithile, inokusebenzisana nezinye iiamolekyu, inika ingqiqo kwintsebenziswano yeprotheni-protein, i-protein-ligand interactions, kunye nokunye.
Ukufunyanwa kweziyobisi:
Ekufunyanweni kweziyobisi, i-Fmoc-D-Tyr(tBu)-OH isebenza njengeyona nto ibalulekileyo ephakathi kwi-synthesis ye-peptides esebenzayo yezinto eziphilayo kunye neziyobisi ezisekelwe kwiprotheni.Ngokuguqulwa kweekhemikhali, iikhompawundi ezinexabiso elinokubakho loxubo mayeza zinokulungiselelwa ukuqhubela phambili izifundo ze-pharmacological and pharmacokinetic.
I-Peptide Synthesis:
I-Fmoc-D-Tyr(tBu)-OH idlala indima ebalulekileyo kwi-soli-phase peptide synthesis.Enkosi kwiqela layo elikhuselayo le-Fmoc, ivumela uqhagamshelo lwe-amino acid esebenzayo kunye nokukhuselwa, ivumela ukuhlanganiswa kwamatyathanga e-peptide ngolandelelwano kunye nemisebenzi ethile.
I-Organic Synthesis:
Kwi-organic synthesis, i-Fmoc-D-Tyr (tBu) -OH isebenza njengebhloko yokwakha ukwakhiwa kwee-molecule ze-organic complex.Isebenzisa ubume bayo beekhemikhali ezithile, inokuhlangabezana neekhemikhali kunye nezinye iimolekyuli, ezikhokelela ekwakhiweni kweemolekyuli zezinto eziphilayo ezinemisebenzi efunwayo.
L-Tyr-OH | D-Tyr-OH | DL-Tyr |
N-Me-Tyr(mna)-OH | N-Me-Tyr(mna).HCL | L-Tyr(tbu)-OH |
L-Tyr-Otbu | D-Tyr-Otbu | Boc-N-Me-L-Tyr(tbu)-OH |
Boc-Tyr-Otbu | Boc-D-Tyr-Otbu | Boc-DL-Tyr-Otbu |
I-Boc-L-Tyr(tBu)-OH | Boc-Tyr (kodwa).Aib | Fmoc-N-Me-Tyr(tBu)-OH |
Fmoc-N-Me-D-Tyr(tBu)-OH | Fmoc-L-Tyr(tBu)-OH | Fmoc-D-Tyr(Et)-OH |
Cbz-N-Me-Tyr(tbu)-OH | Z-Tyr(tbu) | Z-Tyr(tbu).DCHA |
1. Sinikezela ngokwezifiso iimveliso ozifunayo.
2. Umgangatho ophezulu kunye nexabiso elikhuphisanayo linokubonelelwa.
3.Sithembisa ikhosi epheleleyo yenkonzo yokulandelela kuwe.
4. Ikhweshine yomthengisi kunye namaxwebhu obugcisa anokubonelelwa ukuba kucelwe emva kokudibana nesixa esithile.
5. Inkonzo enkulu emva kokuthengisa okanye isiqinisekiso : Nawuphi na umbuzo wakho ungasonjululwa ngokukhawuleza.
6. Ukuthengisa ngaphandle iimveliso ezikhuphisanayo kwaye uzithumele kumazwe angaphandle ngobuninzi obukhulu minyaka le.
I-7.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo.