I-China 13590-42-6 H-Asp(OBzl)-NCA uMvelisi kunye neFactory |Jiayinglai

13590-42-6 H-Asp(OBzl)-NCA

Inkcazelo emfutshane:

Imbonakalo	Umgubo omhlophe
MF	C12H11NO5
MW	249.22
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho
Ukuhamba ngekhonkco elibandayo (-18℃～-22℃)

Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle

Ukuhamba ngekhonkco elibandayo (-18℃～-22℃)

Imeko yokugcina:
Umoya ongaphakathi, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C

Beka ubomi kwishelufa:
Iinyanga ezi-6 ukuya kunyaka omnye

Ubuncinci uMyalelo weQty:
10gm(uthethathethwano)

Isiqinisekiso:COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka
Sidla ngokuba neHPLC, AT, TLC.Ukuba ufuna ngokwenene ukuba sivavanye i-HNMR, qaphela nceda.

Izithethantonye

i-benzyl (1,2,3,4-tetrahydro-2,5-dioxo-1,3-oxazol-4-yl) iacetate;
I-2-[(4S) -2,5-Dioxooxazolidine-4-yl]i-acetic acid benzyl ester;
a-Benzyl-L-aspartic acid N-carboxyanhydride;
(4S) -2,5-Dioxooxazolidine-4-acetic acid benzyl ester;
(4S) -4-(Benzyloxycarbonylmethyl)oxazolidine-2,5-dione;
(4S) -4-[2-(Benzyloxy) -2-oxoethyl]oxazolidine-2,5-dione;
3-(Benzyloxycarbonyl)-N-carboxy-L-alanine anhydride;
(S) -2,5-Dioxo-4-oxazolidineacetic acid phenylmethyl ester;
I-H-ASP(OBZL)-NCA;
L-aspartic acid 4-benzyl ester N-carboxyanhydride;

Ukupakishwa kwangaphakathi

Zisetyenziselwa ukupakisha inani elincinci leemveliso.(1g ukuya kwi-10kg).Kwaye emva koko uwafake kwiibhokisi zekhadibhodi ezinzima.

ukupakisha kwangaphandle

Eyokuqala isoloko isetyenziselwa ukupakisha inani elincinci leemveliso.Eyesibini isetyenziselwa ukupakisha ezinkulu.(15kg ukuya 25kg).Kwaye siya kubhala ngokuthe ngqo phambili.Kwaye uncamathelise irisithi yendawo yokugcina impahla kwisiciko.

Usetyenziso

Uphando lweBiyochemical:
Kwi-peptide synthesis, i-H-Asp (OBzl) -NCA isebenza njengento ebalulekileyo yokwakha i-synthesis yamatyathanga e-peptide aqukethe ukulandelelana kwe-aspartic acid.
Iqela layo le-benzyl ester lisebenza njengeqela elikhuselayo, livumela ukuqaliswa kokuguqulwa kweekhemikhali ezithile ngexesha le-peptide chain synthesis, enokuthi emva koko isuswe phantsi kweemeko ezifanelekileyo ukufumana ulandelelwano olufunwayo lwe-aspartic acid.
Kwizifundo zokuguqulwa kweprotheyini okanye i-peptide, i-H-Asp (OBzl) -NCA ingasetyenziselwa ukwazisa ukuguqulwa kweekhemikhali ezithile ukuphanda indlela ezi nguqulelo zichaphazela ngayo umsebenzi webhayoloji okanye ukusebenzisana kunye nezinye iimolekyuli zeprotheni okanye i-peptide.
Ukufunyanwa kweziyobisi:
I-H-Asp(OBzl)-NCA inokusebenza njenge-precursor yokwenziwa okanye i-intermediate yeemolekyuli zamachiza, evumela ukuqaliswa kwezakhiwo zeekhemikhali ezithile ngexesha loyilo lwamachiza ukufumana abaviwa beziyobisi kunye nemisebenzi ye-biological.
Ngokusabela namanye amaqhekeza amachiza okanye iimolekyuli zebhayoloji esebenzayo, inokuququzelela ukuhlanganiswa kwamachiza asekwe kwipeptide okanye iikhompawundi ze-heterocyclic ezineziphumo ezithile zonyango.
Kwiinkqubo zokufumanisa iziyobisi, i-H-Asp(OBzl)-NCA ingasetyenziselwa ukuhlolwa kwe-high-throughput screening kunye nokuvavanya umsebenzi we-biological ukuvavanya imisebenzi yokulandelelana kwe-peptide eyahlukeneyo okanye abaviwa beziyobisi.
Umzi mveliso wamachiza:
Kwishishini lamachiza, i-H-Asp(OBzl)-NCA isebenza njengento ekrwada okanye ephakathi kwimveliso yeziyobisi zepeptide ezisebenzayo.
Ngokusabela kokujiya kunye nezinye ii-amino acids okanye amaqhekeza eziyobisi, inokuququzelela ukuhlanganiswa kwamachiza e-peptide kunye nemisebenzi ethile yebhayoloji, efana ne-antibiotics, iihomoni, i-enzyme inhibitors, nokunye.
Iqela le-benzyl ester elikhoyo kwisakhiwo salo likhusela i-carboxylic acid ye-aspartic acid, igalelo ekuzinzeni nasekusebenzeni kwakhona kwekhonkco le-peptide ngexesha lokudibanisa.

iimveliso ezinxulumene

L-Lys(tfa)-NCA	Sar-NCA	L-Val-NCA
Lys(Cbz)-NCA	Gly-NCA	L-Leu-NCA
D-Ls(Cbz)-NCA	L-Ala-NCA	D-Leu-NCA
L-Tyr-NCA	D-Ala-NCA	Ile-NCA
D-Tyr-NCA	L-Phe-NCA	Orn (Cbz)-NCA
I-HD-Asp (OBzl)-NCA	L-Glu(Obzl)-NCA
D-Glu (Obzl)-NCA	I-DL-Glu (Obzl)-NCA

Ukongama

1. Sinikezela ngokwezifiso iimveliso ozifunayo.
2. Umgangatho ophezulu kunye nexabiso elikhuphisanayo linokubonelelwa.
3.Sithembisa ikhosi epheleleyo yenkonzo yokulandelela kuwe.
4. Ikhweshine yomthengisi kunye namaxwebhu obugcisa anokubonelelwa ukuba kucelwe emva kokudibana nesixa esithile.
5. Inkonzo enkulu emva kokuthengisa okanye isiqinisekiso : Nawuphi na umbuzo wakho ungasonjululwa ngokukhawuleza.
6. Ukuthengisa ngaphandle iimveliso ezikhuphisanayo kwaye uzithumele kumazwe angaphandle ngobuninzi obukhulu minyaka le.
I-7.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo.

Ngaphambili: 2224-52-4 L-Ala-NCA

Okulandelayo: 2389-45-9 Boc-L-Lys(Cbz)-OH

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