INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
I-Boc-N-Methyl-DL-alanine;
I-Alanine, N- [(1,1-dimethylethoxy)carbonyl]-N-methyl-
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
I-Peptide Synthesis:
I-Boc-N-Me-DL-Ala-OH idlala indima ebalulekileyo kwi-peptide synthesis.NgeBoc (tert-butyloxycarbonyl) iqela elikhuselayo kwi-N-terminus yayo, inokusebenza njengesiqalo se-amino acid okanye iqhekeza eliphakathi lokwandisa amatyathanga epeptide.
Ngokusebenzisa i-peptide synthesis yesigaba esiqinileyo okanye ezinye iindlela zokwenziwa, i-Boc-N-Me-DL-Ala-OH inokudibaniswa nezinye ii-amino acids okanye iipeptide iisegments zokwakha iipeptides okanye iiprotheyini zamaqhekeza kunye nokulandelelana okuthe ngqo kunye nokusebenza.
UPhando lwebhayoloji yeMolekyuli kunye neMolekyuli:
I-Boc-N-Me-DL-Ala-OH ingasetyenziswa njengeprobe okanye ileyibhile kwizifundo zebhayoloji yebhayoloji kunye nemolekyuli.Ngokuyingenisa kwiinkqubo zebhayoloji, abaphandi banokuphanda ukusebenzisana kwayo neeproteni, ii-enzymes, okanye ezinye ii-biomolecules, ngaloo ndlela betyhila iindlela zokulawula eziphantsi kweenkqubo zebhayoloji.
Ukongezelela, ngenxa yokuguqulwa kwayo kwe-N-methylation, i-Boc-N-Me-DL-Ala-OH inokuba nemisebenzi ekhethekileyo yebhayoloji okanye uzinzo, eyenza ukuphononongwa kwemisebenzi yebhayoloji yenoveli okanye uphuhliso lweempawu ezintsha zebhayoloji.
Uyilo noPhuhliso lweziyobisi:
I-Boc-N-Me-DL-Ala-OH ibambe isakhono kuyilo lwamachiza kunye nophuhliso.Ubume bayo obukhethekileyo bekhemikhali kunye nomsebenzi webhayoloji unokwenza ukuba ibe lichiza lomgqatswa okanye isandulela sechiza.
Ngokusebenzisa ukulungiswa kwesakhiwo kunye nokuguqulwa, abaphandi banokuhlola amandla e-Boc-N-Me-DL-Ala-OH ekunyangeni izifo ezithile okanye iimeko, ukubonelela ngesiseko sethiyori sokuqwalaselwa kwayo njengomviwa weziyobisi.
Inzululwazi yeMathiriyeli kunye nosetyenziso:
I-Boc-N-Me-DL-Ala-OH inokuphinda isebenze njenge-monomer esebenzayo okanye isongezo kwi-synthesis yezinto.Ngokusabela okanye i-polymerization kunye nezinye izinto zekhemikhali, iipolima okanye iifilimu ezisebenzayo ezineempawu ezithile zinokulungiswa.
Ezi zixhobo zifumana izicelo kwiindawo ezifana nobunjineli bebhayoloji, ubunjineli bezicubu, kunye neenkqubo zokuhanjiswa kweziyobisi, zibonelela ngesiseko semathiriyeli esitsha sokuqhubela phambili kwiinkalo ezinxulumeneyo.
L-ALA | DL-ALA | D-ALA | HN-Me-L-Ala-OH |
N-Me-L-Ala-OMe | N-Me-L-Ala-Ome.Hcl | Boc-N-Me-Ala-OH | HN-Me-L-Ala-OH |
Fmoc-LN-Me-Ala-OH | Fmoc-N-Me-D-Ala-OH | Cbz-N-Me-D-Ala-OH | Cbz-N-Me-L-Ala-OH |
1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokubunjwa, inokwenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.