INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
Ngomoya, ngolwandle okanye nge-express
Imeko yokugcina:
Umoya ongaphakathi, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C
Ubuncinci boMyinge woMyalelo:
Uthethathethwano
Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka
(S)-4-(2'-METHYLTHIOETHYL)OXAZOLIDINE-2,5-DIONE;
I-L-Met-NCA;
L-Methionine N-carboxyanhydride;
2,5-Oxazolidinedione, 4-[2-(methylthio) ethyl]-, (4S)-;
Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.
Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.
I-Peptide Synthesis: I-Met-NCA iyasebenza kakhulu kwaye inokusetyenziswa njengebhloko yokwakha ye-peptide synthesis.Isabela ngokufanelekileyo kunye ne-amines ukwenza iibhondi ze-peptide, ivumela ukwakhiwa kweepeptides kunye nolandelelwano oluthile kunye neepropati.Le ndlela iluncedo kakhulu ekudityanisweni kweepeptide ezisebenzayo ezinokuthi zisetyenziswe kuphando lwamayeza okanye njengonyango.
Ukufunyanwa kweziyobisi kunye noPhuhliso: I-Methionine yi-amino acid ebalulekileyo edlala indima ebalulekileyo kwiinkqubo zebhayoloji.Ngokubandakanya i-Met-NCA kwiimolekyuli zamachiza, abaphandi banokuzisa iintsalela ze-methionine ezinokuphucula i-bioactivity, ukukwazi ukujolisa, okanye ukuzinza kwamachiza.Le ndlela inokukhokelela ekufumaneni unyango olunoveli kunye neeprofayili eziphuculweyo ze-pharmacological.
Izicelo zeSayensi yeMathiriyeli: I-Met-NCA ingasetyenziselwa ukuhlanganiswa kweepolymers kunye nezixhobo ezine-methionine-based functionalities.Ezi zixhobo zinokubonisa iipropathi ezizodwa ezinje nge-biocompatibility, biodegradability, okanye intsebenziswano ethile neenkqubo zebhayoloji.Zingasetyenziswa kubunjineli beethishu, iyeza lokuhlaziya, okanye uphuhliso lwebhayiloji kwizicelo zonyango.
I-Bioconjugation kunye neProtein Modification: I-Met-NCA ingasetyenziselwa njenge-reagent ye-bioconjugation reactions, ivumela ukudibanisa kweeamolekyu ezahlukeneyo okanye amaqela asebenzayo kwiiprotheni okanye iipeptides.Esi sixhobo sivumela ukuguqulwa kweeprotheni ezineempawu ezifunwayo, ezifana nokuphucula ukunyibilika, ukuzinza, okanye ukujolisa ukukwazi.Ukuphendula kwe-Bioconjugation usebenzisa i-Met-NCA ingasetyenziselwa ukuphuhliswa kwe-protein-based therapeutics, i-biosensors, okanye izixhobo zokuxilonga.
Izifundo ze-Biochemical and Cellular: Ukukwazi ukudibanisa i-peptides kunye neeprotheni eziqulethe i-methionine intsalela usebenzisa i-Met-NCA ibonelela ngesixhobo esinamandla kwizifundo ze-biochemical kunye neselula.Abaphandi banokusebenzisa ezi molekyuli ukuphanda ukusebenzisana kweprotheyini-protein, i-enzyme kinetics, okanye iindlela zokubonisa iselula.I-Met-NCA-derived peptides nayo ingasetyenziswa njenge probes okanye inhibitors ukufunda iinkqubo zebhayoloji kunye neendlela zokugula.
L-Ls(Boc) | Boc-Ls(Cbz)-Ol | Z-Lys(boc)-Ala-Ala-OBzl | Fmoc-L-Lys(Fmoc)-OH |
Lys(Fmoc)-OH | I-Boc-Ls(AC) | L-Lys-oet.2HCl | Fmoc-D-Lys(Boc)-OH |
L-Lys(Cbz)-OH | Boc-L-Lys(Cbz)-OH | D-Lys-Ome.2Hcl | Fmoc-L-Lys(Boc)-OH |
D-Lys(cbz)-OH | Boc-L-Lys(Boc)-OSu | HL-Lys(cbz)-OBzl•HCl | Fmoc-L-Lys-OH·HCl |
H-Lys(Ac)-OH | Boc-L-Lys(Boc)-OH·DCHA | L-Lys(cbz)-Ome.Hcl | Fmoc-Lys-Ome·HCl |
Lys(tfa)-OH | Boc-D-Lys(Boc)-OH | lys(Cbz)-Otbu.HCl | Fmoc-D-Lys-OH·HCl |
D-Lys(tfa)-OH | Boc-L-Lys(Cbz)-OMe | D-Ls(Cbz)-OtBu.HCl | Cbz-Lys(tfa)-OH |
D-Lys (tfa)-NCA | Boc-D-Lys(Cbz)-OH | L-Lys.2Hcl | Cbz-lys (cbz)-osu |
L-Lys(tfa)-NCA | Boc-L-Lys(Cbz)-OH·DCHA | L-Lys-Ome.2Hcl | Cbz-L-Lys(Cbz).DCHA |
Lys(Cbz)-NCA | Boc-L-Lys(Fmoc)-OH | H-Lys-Lys.3HCl | Cbz-L-Lys-OH |
D-Ls(Cbz)-NCA | Fmoc-L-Lys(tfa)-OH | lys-obzl.2hcl | Cbz-L-Lys(Cbz)-OH |
ZL-Lys(Boc).DCHA | I-Fmoc-L-Ls(DDC) | D-Ls(Fmoc) .HCl | Cbz-Lys(AC)-OH |
Ac-Lys-OH | Fmoc-D-Lys(Cbz)-OH | Lys(Fmoc).HCl | Cbz-Lys(BOC)-ome |
I-AC-Lys (Boc)-NH2 | Fmoc-D-Lys(Fmoc)-OH | D-Lys.Hcl | Cbz-Lys(Boc)-Otbu |
AC-Lys(Boc)-OH | Fmoc-L-Lys(Cbz) | D,L-Lys.Hcl | Cbz-L-Lys(BOC)-OH |
H-Lys(Cbz)-OtBu | I-Fmoc-L-Lys(AC) | L-Lys.HCl | Cbz-L-Lys(Fmoc)-OH |
Boc-Lys (Cbz).DCHA | Cbz-L-Lys-Ome.Hcl | Boc-L-Lys-OH | Cbz-L-Lys-obzl.Hcl |
Boc-Lys(tfa)-OH | Z-DL-Lys(cbz)-OH |
1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina