iphepha_ibhena

15776-11-1 Met-NCA

15776-11-1 Met-NCA

Inkcazelo emfutshane:

Imbonakalo Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale.
MF I-C6H9NO3S
MW 175.21
Ubunyulu 98+


Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
Ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
Umoya ongaphakathi, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

I-D-Ls(tfa)-NCA (2)

Izithethantonye

(S)-4-(2'-METHYLTHIOETHYL)OXAZOLIDINE-2,5-DIONE;

I-L-Met-NCA;

L-Methionine N-carboxyanhydride;

2,5-Oxazolidinedione, 4-[2-(methylthio) ethyl]-, (4S)-;

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Usetyenziso

I-Peptide Synthesis: I-Met-NCA iyasebenza kakhulu kwaye inokusetyenziswa njengebhloko yokwakha ye-peptide synthesis.Isabela ngokufanelekileyo kunye ne-amines ukwenza iibhondi ze-peptide, ivumela ukwakhiwa kweepeptides kunye nolandelelwano oluthile kunye neepropati.Le ndlela iluncedo kakhulu ekudityanisweni kweepeptide ezisebenzayo ezinokuthi zisetyenziswe kuphando lwamayeza okanye njengonyango.

Ukufunyanwa kweziyobisi kunye noPhuhliso: I-Methionine yi-amino acid ebalulekileyo edlala indima ebalulekileyo kwiinkqubo zebhayoloji.Ngokubandakanya i-Met-NCA kwiimolekyuli zamachiza, abaphandi banokuzisa iintsalela ze-methionine ezinokuphucula i-bioactivity, ukukwazi ukujolisa, okanye ukuzinza kwamachiza.Le ndlela inokukhokelela ekufumaneni unyango olunoveli kunye neeprofayili eziphuculweyo ze-pharmacological.

Izicelo zeSayensi yeMathiriyeli: I-Met-NCA ingasetyenziselwa ukuhlanganiswa kweepolymers kunye nezixhobo ezine-methionine-based functionalities.Ezi zixhobo zinokubonisa iipropathi ezizodwa ezinje nge-biocompatibility, biodegradability, okanye intsebenziswano ethile neenkqubo zebhayoloji.Zingasetyenziswa kubunjineli beethishu, iyeza lokuhlaziya, okanye uphuhliso lwebhayiloji kwizicelo zonyango.

I-Bioconjugation kunye neProtein Modification: I-Met-NCA ingasetyenziselwa njenge-reagent ye-bioconjugation reactions, ivumela ukudibanisa kweeamolekyu ezahlukeneyo okanye amaqela asebenzayo kwiiprotheni okanye iipeptides.Esi sixhobo sivumela ukuguqulwa kweeprotheni ezineempawu ezifunwayo, ezifana nokuphucula ukunyibilika, ukuzinza, okanye ukujolisa ukukwazi.Ukuphendula kwe-Bioconjugation usebenzisa i-Met-NCA ingasetyenziselwa ukuphuhliswa kwe-protein-based therapeutics, i-biosensors, okanye izixhobo zokuxilonga.

Izifundo ze-Biochemical and Cellular: Ukukwazi ukudibanisa i-peptides kunye neeprotheni eziqulethe i-methionine intsalela usebenzisa i-Met-NCA ibonelela ngesixhobo esinamandla kwizifundo ze-biochemical kunye neselula.Abaphandi banokusebenzisa ezi molekyuli ukuphanda ukusebenzisana kweprotheyini-protein, i-enzyme kinetics, okanye iindlela zokubonisa iselula.I-Met-NCA-derived peptides nayo ingasetyenziswa njenge probes okanye inhibitors ukufunda iinkqubo zebhayoloji kunye neendlela zokugula.

iimveliso ezinxulumene

L-Ls(Boc) Boc-Ls(Cbz)-Ol Z-Lys(boc)-Ala-Ala-OBzl Fmoc-L-Lys(Fmoc)-OH
Lys(Fmoc)-OH I-Boc-Ls(AC) L-Lys-oet.2HCl Fmoc-D-Lys(Boc)-OH
L-Lys(Cbz)-OH Boc-L-Lys(Cbz)-OH D-Lys-Ome.2Hcl Fmoc-L-Lys(Boc)-OH
D-Lys(cbz)-OH Boc-L-Lys(Boc)-OSu HL-Lys(cbz)-OBzl•HCl Fmoc-L-Lys-OH·HCl
H-Lys(Ac)-OH Boc-L-Lys(Boc)-OH·DCHA L-Lys(cbz)-Ome.Hcl Fmoc-Lys-Ome·HCl
Lys(tfa)-OH Boc-D-Lys(Boc)-OH lys(Cbz)-Otbu.HCl Fmoc-D-Lys-OH·HCl
D-Lys(tfa)-OH Boc-L-Lys(Cbz)-OMe D-Ls(Cbz)-OtBu.HCl Cbz-Lys(tfa)-OH
D-Lys (tfa)-NCA Boc-D-Lys(Cbz)-OH L-Lys.2Hcl Cbz-lys (cbz)-osu
L-Lys(tfa)-NCA Boc-L-Lys(Cbz)-OH·DCHA L-Lys-Ome.2Hcl Cbz-L-Lys(Cbz).DCHA
Lys(Cbz)-NCA Boc-L-Lys(Fmoc)-OH H-Lys-Lys.3HCl Cbz-L-Lys-OH
D-Ls(Cbz)-NCA Fmoc-L-Lys(tfa)-OH lys-obzl.2hcl Cbz-L-Lys(Cbz)-OH
ZL-Lys(Boc).DCHA I-Fmoc-L-Ls(DDC) D-Ls(Fmoc) .HCl Cbz-Lys(AC)-OH
Ac-Lys-OH Fmoc-D-Lys(Cbz)-OH Lys(Fmoc).HCl Cbz-Lys(BOC)-ome
I-AC-Lys (Boc)-NH2 Fmoc-D-Lys(Fmoc)-OH D-Lys.Hcl Cbz-Lys(Boc)-Otbu
AC-Lys(Boc)-OH Fmoc-L-Lys(Cbz) D,L-Lys.Hcl Cbz-L-Lys(BOC)-OH
H-Lys(Cbz)-OtBu I-Fmoc-L-Lys(AC) L-Lys.HCl Cbz-L-Lys(Fmoc)-OH
Boc-Lys (Cbz).DCHA Cbz-L-Lys-Ome.Hcl Boc-L-Lys-OH Cbz-L-Lys-obzl.Hcl
Boc-Lys(tfa)-OH Z-DL-Lys(cbz)-OH    

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina


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