INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-(tert-butoxy)phenyl)propanoicacid;
(9H-Fluoren-9-yl)MethOxy]CarbonylN-Me-D-Tyr(tBu)-OH;
(2R) -3-[4-(tert-butoxy)phenyl] -2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoicacid;
(2R) -2- [9H-fluoren-9-ylmethoxycarbonyl (methyl) amino]-3- [4- [(2-methylpropan-2-yl) oxy]phenyl]propanoicacid;
I-N-Fmoc-N-methyl-O-tert-butyl-D-tyrosine;
D-Tyrosine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
I-Fmoc-N-Me-D-Tyr(TBu)-OH, ikwabizwa ngokuba yi-N-α-(9-fluorenylmethoxycarbonyl)-N-α-methyl-D-tyrosine tert-butyl ester, yinto ekhuselweyo evela kwi-amino acid esetyenziswa ngokuqhelekileyo. kwisigaba esiqinileyo se-peptide synthesis.Le ngqungquthela idibanisa iqela elikhuselayo le-Fmoc le-amino terminus kunye ne-tert-butyl (TBu) ester ekhusela i-phenolic hydroxyl iqela le-D-tyrosine.
Iqela leFmoc, njengoko kukhankanyiwe ngaphambili, lizinzile kwaye linyibilika kwizinyibilikisi zendalo, iyenza ilungele ukuhlanganiswa kwepeptide.Inokususwa ngokulula phantsi kweemeko ze-alkaline, ivumela ukuhlanganisana ngokulandelelana kweepeptides kwizixhaso eziqinileyo.I-tert-butyl ester, ngakolunye uhlangothi, ikhusela iqela le-phenolic hydroxyl ye-D-tyrosine, iqinisekisa ukuzinza kunye nokucoceka kwayo ngexesha lenkqubo yokudibanisa.
Ukusetyenziswa okuphambili kwe-Fmoc-N-Me-D-Tyr (TBu)-OH kukulungiselela i-peptides equkethe i-D-tyrosine.Ngokusebenzisa le mveliso ye-amino acid, abaphandi banokuzisa i-D-tyrosine kunye neqela le-amino kunye ne-phenolic hydroxyl ekhuselweyo kulandelelwano lwe-peptide.Oku kunika ulawulo oluchanekileyo phezu kwesakhiwo se-peptide kwaye iququzelele ukuqaliswa kwezinye i-amino acids kunye nokuguqulwa kwizikhundla ezithile ngaphakathi kwekhonkco le-peptide.
I-D-Tyrosine yi-amino acid engeyiyo yendalo enokuthi ifakwe kwiipeptides ukufunda iipropati zabo zebhayoloji okanye ukwenza i-peptide analogs kunye nemisebenzi eguquliweyo.Iipeptide eziqulethe i-D-tyrosine zinokuba nemisebenzi eyahlukeneyo yezinto eziphilayo xa kuthelekiswa noogxa babo be-L-tyrosine, ngenxa yokwahlukana kwe-stereochemical phakathi kwee-amino acid ezimbini.
N-Me-Tyr(Me)-OH.HCl | Boc-N-Me-L-Tyr(tbu)-OH | Fmoc-N-Me-L-Tyr(tBu)-OH | Cbz-N-Me-Tyr(tbu)-OH |
FMOC-N-Me-D-Tyr(me)-OH | Boc-N-Me-L-Tyr(bzl)-OH | Fmoc-N-Me-L-Tyr(bzl)-OH | Boc-N-Me-D-Tyr(bzl)-OH |
1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokubunjwa, inokwenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.