iphepha_ibhena

340-90-9 N-Pht-Glu

340-90-9 N-Pht-Glu

Inkcazelo emfutshane:

Imbonakalo Umgubo omhlophe ukuya kumhlophe
MF C13H11NO6
MW 277.23
Ubunyulu 98+


Iinkcukacha zeMveliso

Imeko yezothutho
Inokuba kubushushu obuqhelekileyo

Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle

Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi

Beka ubomi kwishelufa
Malunga neminyaka emi-2

Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)

Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20                      

Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.

Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.

I-D-Ls(tfa)-NCA (2)

Izithethantonye

(2S) -2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)pentanedioicacid;

i-n-phthalyl-l-glutamicacid;

I-N-PHTHALIMIDEL-GLUTAMINCACID;

I-N-PHTHALOYL-L-GLUTAMICACID;

I-PHTHALYL-L-GLUTAMICACID;

I-PHTHALOYL-L-GLUTAMICACID;

PHT-GLU-OH;

PHGA

Ukupakishwa kwangaphakathi

Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.

Ukupakisha kwangaphakathi 2
Ukupakisha kwangaphakathi 1
Ukupakisha kwangaphakathi 3

ukupakisha kwangaphandle

I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.

Ukupakisha kwangaphandle 3
Ukupakisha kwangaphandle 2
Ukupakisha kwangaphandle 1

Usetyenziso

I-PHTHALYL-L-GLUTAMIC ACID ingasetyenziselwa ukwenza (R)-(+)-THALIDOMIDE.Yi-glutamic acid derivative engenampembelelo yonyango kwiqhenqa, kwaye isetyenziswa kunye namachiza e-antileprosy ukunciphisa ukusabela kweqhenqa kunye nokunyanga iintlobo ezahlukeneyo zesifo seqhenqa, ezifana ne-lymph nodes eyandisiweyo, i-erythema nodosum, umkhuhlane, i-arthralgia kunye ne-neuralgia kunye nokusebenza kakuhle. .
Iziphumo ze-immunomodulatory ze-thalidomide zahluka kakhulu ngokweemeko zovavanyo, kunye neziphumo eziphikisanayo ngamanye amaxesha.Iimpembelelo kwi-lymphocytes ziquka ukuhla kweeseli ze-CD4 + kunye nokuvuselelwa kweeseli ze-CD8 +, okubangelwa ukuhla kwe-CD48 ratio.
Ukongeza, i-thalidomide ibonakala ikhuthaza utshintsho ukusuka kwi-Th1 ukuya kwi-Th2 impendulo.
I-Cyclosporine kunye ne-thalidomide esebenza kwii-subtypes ze-T lymphocytes, i-Th1 kunye ne-Th2, kunye ne-Thd yafunyanwa ukuba ifake kwaye iphucule i-IL-4 kunye ne-IL-5, inqanda ukuhlanganiswa kwe-interferon gamma (IFN-γ) nge-phytohemagglutinin-stimulated human. i-peripheral blood monocytes, kunye nokunciphisa amanqanaba e-TNF-α, i-IL-6, kunye ne-IL-10 mRNAs, ngaphandle kwempembelelo kumanqanaba e-IL-12 kunye ne-IFN-γ mRNA ayinayo impembelelo

iimveliso ezinxulumene

HL-Glu-OH I-HD-Glu-OH I-DL-Glu-OH I-Boc-L-Glu-OH
I-Boc-D-Glu-OH I-Boc-Glu(trt)-OH Fmoc-L-Glu-OH Fmoc-D-Glu-OH
Cbz-L-Glu-OH Cbz-D-Glu-OH Cbz-L-Glu-Otbu Cbz-L-Glu(Oet)-OH

Kutheni Khetha Thina

1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokungunda, ingenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.


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