China 3415-08-5 L-Tyr-NCA uMvelisi kunye neFactory |Jiayinglai

3415-08-5 L-Tyr-NCA

Inkcazelo emfutshane:

Imbonakalo	Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale
MF	C10H9NO4
MW	207.18
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
umoya ophakathi, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

Izithethantonye

iTyrosine, iNCA;

I-N-Carboxy-L-tyrosine anhydride;

(4S) -4 - [(4-Hydroxyphenyl) methyl] -2,5-oxazolidinedione;

L-Tyrosine N-carboxyanhydride;

(2,5-Oxazolidinedione,4-[(4-hydroxyphenyl)Methyl]-, (4S)-;

I-N-Carbonyl-L-Tyrosine Anhydride

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Usetyenziso

3415-08-5 L-Tyr-NCA yenye ye-intermediates ye-Glatiramer Acetate.

I-Glatiramer Acetate yi-agent ye-peptide elungiselelwe ngokwenziwa eyenziwe ngama-amino acids amane: i-glutamic acid, i-alanine, i-tyrosine, kunye ne-lysine.Ukusetyenziswa kwayo okuphambili kunyango lwe-Multiple Sclerosis (MS), isifo esingapheliyo, esivuthayo, esiphazamisayo esichaphazela inkqubo ye-nervous central.Ngokusebenzisa indlela "yokunyanzeliswa kwe-bypass," i-Glatiramer Acetate yenza i-immunomodulatory kunye ne-anti-inflammatory effects kwi-MS, inyusa amanqanaba e-brain-derived neurotrophic factor (BDNF), ukunciphisa ukuvuvukala okubangelwa ukuchithwa kwe-demyelination, kunye nokukhuthaza ukukhula kwee-axons kunye ne-myelin sheaths.

Ehlabathini lonke, i-Glatiramer Acetate ifumene ukusetyenziswa ngokubanzi.Ngokomzekelo, eUnited States, ithengiswa phantsi kwegama le-brand Copaxone kwaye yamkelwe yi-Food and Drug Administration (FDA) kunyango lwe-Multiple Sclerosis.Kumazwe aseNtshona ane-MS ephezulu, ukusebenza kwayo kunye nokunyamezela kuye kwaqatshelwa ngokubanzi.

E-China, nge-28 kaJuni, i-2023, "I-Glatiramer Acetate Injection" ifumene ngokusemthethweni imvume evela kuLawulo lweeMveliso zoNyango lweSizwe (i-NMPA) kunyango lwezigulane zabantu abadala abane-relapsing-remitting Multiple Sclerosis (MS), kuquka i-clinical isolated syndrome, i-relapsing-remitting I-MS, kunye ne-MS eqhubekayo esebenzayo.

iimveliso ezinxulumene

L-Gly-NCA	L-Ala-NCA	D-Ala-NCA	L-Val-NCA
D-Leu-NCA	DL-leu-NCA	L-Phe-NCA	D-Tyr-NCA
L-Tyr(bzl)-NCA	L-Glu(Obzl)-NCA	I-D-Asp(OBzl)-NCA	L-Lys(tfa)-NCA
L-Lys(Cbz)-NCA	D-Ls(Cbz)-NCA	Sar-NCA

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
I-3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina