INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
(2S) -2-(tert-Butoxycarbonylamino) -3-methoxy-propanoicacid;
(S) -N-BOC-2-AMINO-3-METHOXY-PROPIONICACID;
I-N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE;
N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-LSERINEDICYCLOHEXYLAMMONIUMSALT;
N-ALPHA-T-BOC-O-METHYL-L-SERINE;
I-BOC-(S) -2-AMINO-3-METHOXYLPROPANOICACID;
I-BOC-(S) -2-AMINO-3-METHOXYPROPIONICID
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
Uphando lweBiyochemical:
I-Boc-Ser (Me) -OH isebenza njenge-reagent ye-biochemical exabisekileyo kwi-protein synthesis, i-enzymatic reactions, kunye nezifundo zokusebenzisana kwee-molecular.
Iyakwazi ukulinganisa umsebenzi we-serine yendalo, ukwenza amatyathanga e-peptide kunye namanye amino acids okanye amacandelo e-peptide ukubonelela ngengqiqo kwisakhiwo seprotheni kunye nomsebenzi.
Ukufunyanwa kweziyobisi:
I-Boc-Ser(Me)-OH idlala indima ebalulekileyo ekubhaqweni kweziyobisi ngenxa yomsebenzi wayo webhayoloji.
Ngohlengahlengiso lwesakhiwo kunye nokulungiswa, inokusebenza njengomgqatswa weziyobisi okanye isandulela sechiza kuphuhliso lwenoveli yonyango.
Ukongeza, inokusetyenziswa kwi-synthesis yamachiza asekwe kwi-peptide kunye nemisebenzi ye-pharmacological okanye njengendawo ephakathi kwi-synthesis yeziyobisi.
I-Organic Synthesis:
Kwi-organic synthesis, i-Boc-Ser (Me) -OH isebenza njenge-synthetic intermediate yokwakhiwa kwee-molecule ze-organic complex.
I-Boc kunye ne-O-methyl amaqela akhuselayo kwisakhiwo sayo avumela ukukhuselwa kwamaqela athile asebenzayo, ukuthintela ukuphendulwa kwecala elingathandekiyo ngexesha lenkqubo yokwenziwa.
Emva kokugqitywa kwe-synthesis, la maqela akhuselayo anokususwa ngokukhethiweyo ukuze afumane i-molecule efunwayo.
I-Peptide Synthesis:
I-Boc-Ser (Me) -OH isetyenziswa ngokuqhelekileyo njengesiqalo se-amino acid kwi-solid-phase peptide synthesis.
Ngokongezwa ngokuthe ngcembe kwezinye iintsalela ze-amino acid, amatyathanga epeptide anolandelelwano oluthile kunye nezakhiwo zinokudityaniswa.
La matyathanga e-peptide anokusebenza kufundo lweprotein structure-function relationship, uphuhliso lwenoveli yamachiza asekwe kwipeptide, okanye njengee-reagents zokuxilonga.
L-Ser | I-H-DL-Ser-OH | D-Ser-OH |
L-Ser-Ol | L-Ser-Ol | L-Ser(Me)-OH |
HL-Ser(Me)-OH.HCl | I-DL-Ser(Me)-OH | D-Ser(mna) |
I-HL-Ser(tBu)-OH | I-D-Ser(tBu)-OH | I-D-Ser(bzl) |
D-Ser(bzl).HCl | I-HL-Ser(Bzl)-OH.HCl | I-HL-Ser(Bzl)-OH |
HL-Ser(Bzl)-OL.HCl | HL-Ser-OMe.HCl | L-Ser-Oet.Hcl |
HL-Ser-OBzl.HCl | HL-Ser-OBzl | DL-Ser-Obzl.Hcl |
D-Ser-Obzl.Hcl | I-Boc-L-Ser(Bzl)-OH | I-Boc-DL-Ser(Bzl)-OH |
Boc-Ser(Bzl)-ol | I-Boc-D-Ser(Bzl)-OL | Boc-L-Ser-OMe |
Boc-L-Ser-Obzl | Boc-L-Ser(cl)-OMe | Fmoc-L-Ser(bzl)-OH |
Fmoc-D-Ser(bzl)-OH | Fmoc-N-Me-Ser(bzl) | I-ZL-Ser(Bzl)-OH |
Cbz-D-Ser(Bzl)-OH | Cbz-L-Ser-Ome | Cbz-DL-Ser-ome |
Cbz-D-Ser-Ome | Cbz-L-Ser-Obzl |
1. Malunga notshintshiselwano: Nceda undithumelele i-imeyile okanye uncokole nam ngokulula kwakho.
2. Umgangatho ophezulu: Ukusebenzisa izinto eziphezulu kunye nokuseka inkqubo yokulawula umgangatho ongqongqo, ukwabela abantu abathile abajongene nenkqubo nganye yokuvelisa, ukusuka ekuthengeni izinto eziluhlaza ukupakisha.
3. Iworkshop yokubunjwa, imodeli eyenziwe ngokwezifiso ingenziwa ngokobuninzi.
4. Sinikezela ngeyona nkonzo ibalaseleyo njengoko sinayo.Iqela lokuthengisa elinamava sele lisebenzela wena.