INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
(R) -2-((benzyloxycarbonyl)(methyl)amino)-3-methylbutanoicacid;
Cbz-N-Methyl-D-Valine;
N-Methyl-N-Cbz-D-valine;
N-Methyl-N-[(phenylmethoxy)carbonyl]-D-valine;
I-N-Benzyloxycarbonyl-N-methyl-D-valine;
Cbz-N-Me-D-Val-OH;
(2R)-2-{[(benzyloxy)carbonyl](methyl)amino}-3-methylbutanoicacid;
N-Cbz-N-methyl-D-valine
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
I-Peptide Synthesis: I-Cbz-N-Me-D-Val-OH isebenza njengebhloko yokwakha ebalulekileyo kwi-peptide synthesis yesigaba esiqinileyo.Iqela layo le-benzoyl (Cbz) elikhuselayo liqinisekisa ukuzinza ngexesha lenkqubo yokudibanisa, ngelixa i-N-methylation iphakamisa ukunyibilika kunye nokusebenza kwakhona.Oku kuvumela ukuqaliswa ngokufanelekileyo kweentsalela ze-D-valine kumatyathanga e-peptide, okukhokelela kwiipeptides ezicocekileyo kunye nemisebenzi efunwayo yebhayoloji.
Izifundo zebhayoloji: Iipeptides zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, ezinjengokudluliselwa komqondiso, ukulawulwa kwe-enzyme, kunye nokuphendula komzimba.Ukufumaneka kwe-Cbz-N-Me-D-Val-OH kuvumela abaphandi ukuba badibanise i-peptides equkethe i-D-valine residues, ebenza bakwazi ukuphanda iindima ezithile kunye nokusebenzisana kwezi peptides kwiinkqubo zebhayoloji.
Ukufunyanwa kweziyobisi kunye noPhuhliso: Amachiza asekelwe kwi-Peptide afumene ingqwalasela ebalulekileyo kwiminyaka yakutshanje ngenxa yokucaciswa okuphezulu kunye netyhefu ephantsi.I-Cbz-N-Me-D-Val-OH, njengenxalenye ephambili kwi-peptide synthesis, ingasetyenziswa kuyilo kunye nophuhliso lwamachiza anoveli epeptide.Ngokudibanisa iintsalela ze-D-valine kula machiza, abaphandi banokwenza unyango olusebenzayo oluneempawu ezizodwa zebhayoloji.
L-Val-OH | DL-Val | HD-Val-OH | N-Me-L-Val-OH |
N-Me-L-Val.HCl | N-Me-D-Val | N-Me-D-Val-OH·HCl | N-Me-L-Val-Ome.HCl |
N-Me-D-Val-Ome.HCl | N-Me-Val-Obzl.HCl | N-Me-D-Val-Obzl.HCl | N-Me-Val-Obzl.Tos |
Boc-N-Me-Val-OH | Boc-N-Me-D-Val-OH | Fmoc-N-Me-Val-OH | Fmoc-N-Me-DL-Val-OH |
Fmoc-N-Me-D-Val-OH | Cbz-N-Me-L-Val-OH |
1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokubunjwa, inokwenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.