INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
(Tert-Butoxy)CarbonylN-Me-Tyr(tBu)-OH;
(2R)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-[4-(tert-butoxy)phenyl]propanoicacid;
Boc-L-MeTyr(tBu)-OH;
I-N-Boc-N-methyl-O-tert-butyl-L-tyrosine;
L-Tyrosine,N-[(1,1-dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-N-methyl-;
I-N-α-(t-Butoxycarbonyl)-N-α-methyl-O-(t-butyl) -L-tyrosine;
(S)-3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)(methyl)amino)propanoicacid
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Ke ngoko, sixelele ngemfuno yakho phambi kokupakisha ukuba unezicelo ezizodwa.
I-1kg ukuya kwi-25kg Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
I-Peptide Synthesis:
I-Boc-N-Me-L-Tyr (Tbu) -OH i-amino acid ekhuselweyo esetyenziswa ngokuqhelekileyo kwi-peptide synthesis (SPPS) kunye nezinye iindlela ze-peptide synthesis.Ngamaqela omabini e-N-terminal kunye ne-side-chain hydroxyl amaqela akhuselweyo, igcina uzinzo ngexesha lokwandiswa kwetsheyini ye-peptide, inqanda ukuphendula okungafunekiyo.
Emva kokuba i-peptide chain synthesis igqityiwe, amaqela akhuselayo anokususwa phantsi kweemeko ezifanelekileyo, eveza i-amino yamahhala kunye namaqela e-hydroxyl, ngaloo ndlela enikezela i-peptide efunwayo okanye iprotheni.
Ubunjineli beProtheyini:
Kubunjineli beprotheyini, le amino acid ikhuselweyo inokusetyenziselwa ukulungiswa kweprotheyini yendawo ethile.Ngokuphendula i-Boc-N-Me-L-Tyr (Tbu) -OH kunye neendawo ezithile kwiprotheni, i-methylated tyrosine residue ingangeniswa, iguqule iimpawu zeprotheni kunye nomsebenzi.
Uyilo noPhuhliso lweziyobisi:
I-Methylated tyrosine inokubonisa imisebenzi ethile yebhayoloji okanye iipropathi ze-pharmacokinetic kuyilo oluthile lwamachiza.Ngokusebenzisa i-Boc-N-Me-L-Tyr (Tbu) -OH njengebhloko yokwakha, abaphandi banokuphonononga ukuphumelela konyango kunye neempawu ze-pharmacological ze-molecule zamachiza ezine-methylated tyrosine.
UPhando lweBiyochemical kunye neBiological:
Kuphando lwe-biochemical kunye ne-biological, le-amino acid ekhuselweyo ingasebenza njengesixhobo sokufunda indima ye-methylated tyrosine kwintsebenziswano yeprotheni, ukuhanjiswa komqondiso, umsebenzi we-enzyme, kunye nezinye iinkalo.
I-Bioconjugation kunye nokuFakwa:
Amaqela e-methyl kunye ne-hydroxyl ekhuselweyo ye-Boc-N-Me-L-Tyr (Tbu) -OH yenza kube yinto efanelekileyo yokukhetha i-bioconjugation kunye neeleyibhile ukuphendula.Ngokususa amaqela akhuselayo kunye nokusabela kunye nezinye iimolekyuli okanye izinto ezisebenza ngebhayoloji, iimolekyuli ezinophawu olunemisebenzi ethile yebhayoloji zinokulungiswa.
N-Me-Tyr(Me)-OH | FMOC-N-Me-D-Tyr(me)-OH | Fmoc-N-Me-L-Tyr(tBu)-OH | Cbz-N-Me-Tyr(tbu)-OH |
Fmoc-N-Me-D-Tyr(tBu)-OH | Boc-N-Me-L-Tyr(bzl)-OH | Fmoc-N-Me-L-Tyr(bzl)-OH | Boc-N-Me-D-Tyr(bzl)-OH |
1. Malunga ne-MOQ: Sinokuyilungisa ngokwemfuno yakho.
2. Malunga nesampuli: Isampuli idinga umrhumo wesampuli, onokuthi ube yimpahla yokuqokelela okanye unokuhlawula kuthi kwangaphambili.
3. Iworkshop yokubunjwa, inokwenziwa ngokwezifiso ngokwenani leemodeli.
4. Sinikezela ngeyona nkonzo ibalaseleyo.Iqela lokuthengisa elinamava sele lisebenzela wena.
5. Malunga notshintshiselwano: Nceda uthumele i-imeyile okanye uxoxe nam ngokufanelekileyo.