China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester uMvelisi kunye neFactory |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Inkcazelo emfutshane:

Imbonakalo	Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale.
MF	I-C16H22N2O6
MW	338.36
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

Izithethantonye

(S)-ethyl 2-(tert-butoxycarbonylaMino)-3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, i-ethyl ester

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Usetyenziso

Nidanib, yikhemikhali.Igama lekhemikhali 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland ye methyl] - 2 - i-oksijini -, i-methyl ester, (z) - Ngokonyango, le mveliso isetyenziselwa ukunyanga i-idiopathic pulmonary fibrosis (IPF).
U-Nidanib uye wafunda izigulane ze-1,529 ezine-idiopathic pulmonary fibrosis (IPF) kwizilingo ezininzi zeklinikhi.Idatha yokhuseleko enikezelweyo isekelwe ekuthelekisweni kwezigulane ze-1061 ezinikwe i-nidanib i-150 mg kabini imihla ngemihla kunye ne-placebo kwiiveki ezimbini ze-52-isigaba se-3, i-randomized, i-double blind, izifundo ezilawulwa yi-placebo (INPULSIS-1 kunye ne-INPULSIS-2).Iziganeko ezimbi kakhulu ezixhaphakileyo ezinxulumene nokusetyenziswa kwe-nidanib zibandakanya urhudo, isicaphucaphu kunye nokuhlanza, intlungu yesisu, ukulahlekelwa ngumdla, ukulahleka kwesisindo, kunye ne-enzymes yesibindi ephakamileyo.Nceda ubhekisele ku- [IiNgcaciso] zolawulo lweziphumo ezibi ezihambelanayo.UHlelo lweZiko eliCwangcisiweyo (i-SOC) le-MedDRA libonelela ngesishwankathelo seempendulo ezingalunganga kunye nokuhlelwa rhoqo.
I-Nidanib yinxalenye ye-P-gp (jonga i-Pharmacokinetics).Kwisifundo esithile sokusebenzisana kweziyobisi, ukulawulwa okudibeneyo kwe-ketoconazole, i-P-gp inhibitor enamandla, ukunyuka kwe-exposure ye-nidanib kumaxesha e-1.61 kwindawo ephantsi kwe-curve (AUC) kunye namaxesha e-1.83 nge-peak concentration (Cmax).
Kuphononongo lokusebenzisana neziyobisi kunye ne-P-gp inducer rifampicin enamandla, ukutyhileka kwi-nidanib kwehle ukuya kutsho kwi-50.3%, njengoko kulinganiswe ngendawo ephantsi kwegophe (AUC), xa kudityaniswa ne-rifampicin xa kuthelekiswa ne-Nidanib yodwa.Ngokugxininiswa kwencopho (Cmax), yehla ukuya kwi-60.3%.
Xa ilawulwa ngokudibeneyo nale mveliso, i-P-gp inhibitors enamandla (umzekelo, i-ketoconazole okanye i-erythromycin) inokunyusa ukutyhila kwi-nidanib.Kwezi meko, ukunyamezelana kwesigulane kwi-nidanib kufuneka kubekwe iliso elibukhali.Ukulawulwa kweempembelelo ezimbi kunokufuna ukuyeka, ukunciphisa idosi, okanye ukuyeka unyango ngale mveliso (jonga [Ukusetyenziswa kunye nedosi]).
I-P-gp inducers ezinamandla (umzekelo, i-rifampicin, i-carbamazepine, i-phenytoin kunye ne-St. John's wort) inokunciphisa ukuchanabeka kwi-nidanib.Iindibaniso ezizezinye ezingenayo okanye ezincinci zokungeniswa kwe-P-gp kufuneka ziqwalaselwe.

iimveliso ezinxulumene

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
I-Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2)-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2).H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
I-D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
I-HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	I-Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
I-3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina