INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
T-BUTYLOXYCARBONYL-L-ASPARAGINE;
I-TBOC-L-ASPARAGINE;
I-N-TERT-BUTOXYCARBONYL-L-ASPARAGINE;
I-NT-BUTOXYCARBONYL-L-ASPARAGINE;
I-NT-BOC-L-ASPARAGINE;
N2-[(1,1-Dimethylethoxy)carbonyl]-L-asparagine;
I-NALPHA-BOC-L-ASPARAGINE;
I-N-ALPHA-T-BOC-L-ASPARAGINE
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Iphakheji yesibini yokuqala ibonakala ngokucacileyo, kodwa akukho mfuneko yakukhathazeka ngaloo nto.Kuba siya kuba nokupakisha kwangaphandle.
Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Ukuba ufuna nayiphi na i-documentary, nceda usazise kwangaphambili.Siza kuzifaka kuyo.Okanye uvule iimveliso ezipakishiweyo kunokuchaphazela inkangeleko yayo yangaphandle.
I-Boc-L-Asn-OH, eyaziwa ngokuba yi-BOC-L-Asparagine, iyimfuneko ebalulekileyo ye-amino acid kunye nezicelo ezahlukeneyo.
Okokuqala, i-Boc-L-Asn-OH ifumana ukusetyenziswa ngokubanzi kwi-biochemistry kunye nokufunyanwa kweziyobisi.Isebenza njengenxalenye ephambili kwi-peptide synthesis, eyenza ukwakhiwa kwamatyathanga e-peptide kunye nemisebenzi ethile yebhayoloji.Ngenxa yeempawu zayo zeekhemikhali ezikhethekileyo, i-Boc-L-Asn-OH inokusabela kunye nezinye i-amino acids okanye i-compounds, ekhokelela ekuveliseni izidakamizwa ezinoveli okanye iamolekyu ze-bioactive ezinemisebenzi eyahlukileyo.
Okwesibini, i-Boc-L-Asn-OH nayo inezicelo kwi-biotechnology kunye nebhayoloji yemolekyuli.Inokuthi isebenze njenge-amino acid ekhusela i-monomer, ikhusela amaqela asebenzayo kwezinye i-amino acids okanye i-peptide chains kwii-chemical reactions ezingafunekiyo ngexesha lokudibanisa okanye ukuhlanjululwa.Ukongezelela, i-Boc-L-Asn-OH ingasetyenziselwa ukuguqulwa kwendawo ethile kubunjineli beprotheni, ukuguqula isakhiwo kunye nomsebenzi weeprotheni.
Ngapha koko, ngokweendlela zobuchule bokuvelisa, i-Boc-L-Asn-OH inokwenziwa ngokusabela kweekhemikhali ezithile.Ngokuqhelekileyo, ilungiswa ngokusebenzisa i-tert-butoxycarbonyl chloride (okanye i-azide) kunye ne-L-asparagine njengezinto zokuqala.Ukusabela kwe-acylation kulandelwa yi-acidification usebenzisa i-citric acid kwaye emva koko ukuhlanjululwa ngokuphindaphindiweyo.Le nkqubo yokuvelisa yenza ukuba ulungelelwaniso olukhulu lwe-Boc-L-Asn-OH, ukuhlangabezana neemfuno zezicelo zayo ezahlukeneyo.
L-Asn.H2O | D-Asn.H2O |
D-Asn | L-Asn(Trt)-OH |
Boc-L-Asn-Onp | Boc-L-Asn-OH |
Boc-D-Asn | Boc-L-Asn-Oet |
Boc-L-Asn-Obzl | Fmoc-L-Asn-OH |
Fmoc-D-Asn(Trt)-OH | Fmoc-L-Asn(Trt)-OH |
Cbz-L-Asn-OH | Cbz-L-Asn(Trt)-OH |
1. Sinikezela ngokwezifiso iimveliso ozifunayo.
2. Umgangatho ophezulu kunye nexabiso elikhuphisanayo linokubonelelwa.
3.Sithembisa ikhosi epheleleyo yenkonzo yokulandelela kuwe.
4. Ikhweshine yomthengisi kunye namaxwebhu obugcisa anokubonelelwa ukuba kucelwe emva kokudibana nesixa esithile.
5. Inkonzo enkulu emva kokuthengisa okanye isiqinisekiso : Nawuphi na umbuzo wakho ungasonjululwa ngokukhawuleza.
6. Ukuthengisa ngaphandle iimveliso ezikhuphisanayo kwaye uzithumele kumazwe angaphandle ngobuninzi obukhulu minyaka le.
I-7.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo.