INCWADANA YEENDABA
Ngemibuzo malunga neemveliso zethu okanye uluhlu lwamaxabiso, nceda ushiye i-imeyile yakho kuthi kwaye siya kuqhagamshelana phakathi kweeyure ezingama-24.
BUZA NGOKUImeko yezothutho
Inokuba kubushushu obuqhelekileyo
Cebisa indlela yokuthumela ngenqanawa
Ngomoya Ngomhlaba Ngolwandle
Imeko yokugcina:
Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Beka ubomi kwishelufa
Malunga neminyaka emi-2
Ubuncinci uMyalelo weQty:
1kg (uthethathethwano)
Isiqinisekiso:COA, indawo yokunyibilika, iSpecificRotation [α]D20
Siza kuthumela nayiphi na idatha oyifunayo.Ungayibona idatha ngaphambili njengereferensi.
Kwiimveliso ezilungiselelwe wena, sithumela eyona datha intsha emva kokuba iphumile.
i-methyl 2-tert-butoxycarbonylamino-2-methylpropanoate;
i-methyl 2-aminobutoxycarbonyl-2-methylpropanoate;
I-N-tert-butoxycarbonyl-α-methylalanine i-methyl ester;
i-methyl 2-(tert-butoxycarbonylamino) -2-methylpropanoate;
N-(tert-butoxycarbonyl) -α-methylalanine methyl ester;
i-methyl N-(tert-butoxycarbonyl) -2-methyl-alaninate;
Zihlala zisetyenziselwa ukupakisha umgubo.Kuxhomekeke kwiimfuno zabathengi.Siza kuqinisekisa iphakheji nawe ngaphambi nasemva kokuba iimveliso ziphuma kwaye sikuthumelele imifanekiso.
Ukupakisha kwangaphandle kunzima.Kwaye kunzima ukusika kunye nomonakalo.Inokukhusela iimveliso zakho ngokugqibeleleyo.
I-Peptide Synthesis: I-Boc-Aib-Ome isebenza njengebhloko yokwakha kwi-peptide synthesis yesigaba esiqinileyo.Inokudityaniswa kumatyathanga epeptide ukwazisa ulandelelwano oluthile lwe-amino acid.Iqela elikhuselayo le-Boc livumela ukusabela okulawulwayo kokudibanisa, ukuqinisekisa ukudityaniswa okuchanekileyo kweepeptides.Nje ukuba i-peptide synthesis igqityiwe, iqela le-Boc linokususwa ukubonisa ukusebenza kwe-amino ukwenzela uhlengahlengiso olongezelelweyo okanye ukudibanisa.
Ukufunyanwa kweziyobisi: I-Boc-Aib-Ome ifumana izicelo kuyilo lwenoveli yamachiza asekwe kwipeptide.Ngokudibanisa le amino acid ephuma kulandelelwano lwepeptide, abaphandi banokuphonononga ii-arhente zonyango ezinokubakho ngemisebenzi eyodwa yebhayoloji.Iqela elikhuselayo le-Boc libonelela ngokuzinza ngexesha lenkqubo yokwenziwa, eyenza ukulungiswa kwe-peptide conjugates kunye neempawu eziphuculweyo ze-pharmacokinetic.
I-Bioconjugation: I-Boc-Aib-Ome ingasetyenziselwa ukuphendula kwe-bioconjugation ukudibanisa i-peptides okanye iiprotheni kwezinye iimolekyuli zezinto eziphilayo.Ukusebenza kwe-methyl ester kwenza uncamathiselo oludibeneyo kwiimolekyuli ezahlukeneyo, ezinjenge-antibodies, iicarbohydrates, okanye ezinye iipeptides.Oku kuvumela ukuyilwa kweenkqubo zonikezelo ekujoliswe kuzo, ii-biosensors, okanye ezinye i-bioactive conjugates ezinomsebenzi ophuculweyo.
Izifundo ze-Biochemical: I-Boc-Aib-Ome inokuqeshwa njengesixhobo kwizifundo ze-biochemical ukuphanda i-protein-protein interactions, i-enzyme kinetics, okanye i-substrate ethile.Ngokubandakanya le mveliso ye-amino acid kwi-peptides esetyenziswa njenge-probes okanye i-inhibitors, abaphandi banokufumana ukuqonda kwiindlela zeenkqubo zebhayoloji.
Ayib | Boc-Tyr (kodwa).Aib | 2-Aib-Ome.Hcl |
2-Aib-Ome.Hcl | 2-Aib-Ome.Hcl | L-Aib-Oet.Hcl |
Boc-Aib-OH | Boc-Aib-OH | Boc-Aib-OH |
Boc-aib-Ome | Fmoc-Aib-OH | Fmoc-Aib-OH |
Fmoc-Aib-OH | Fmoc-Aib-OH | Fmoc-Aib-OH |
Fmoc-Aib-OH | Z-Aib-OH | Cbz-Aib-Otbu |
1. Sinikezela ngokwezifiso iimveliso ozifunayo.
2. Umgangatho ophezulu kunye nexabiso elikhuphisanayo linokubonelelwa.
3.Sithembisa ikhosi epheleleyo yenkonzo yokulandelela kuwe.
4. Ikhweshine yomthengisi kunye namaxwebhu obugcisa anokubonelelwa ukuba kucelwe emva kokudibana nesixa esithile.
5. Inkonzo enkulu emva kokuthengisa okanye isiqinisekiso : Nawuphi na umbuzo wakho ungasonjululwa ngokukhawuleza.
6. Ukuthengisa ngaphandle iimveliso ezikhuphisanayo kwaye uzithumele kumazwe angaphandle ngobuninzi obukhulu minyaka le.
I-7.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo.