China 130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester Umenzi kunye Factory |Jiayinglai

130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester

Inkcazelo emfutshane:

Imbonakalo	Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale.
MF	C12H21NO6
MW	275.3
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, ubushushu beGumbi

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

Izithethantonye

i-dimethyl(tert-butoxycarbonyl) -D-glutamate;
(R) -2-tert-Butoxycarbonylamino-pentanedioic acid dimethyl ester;
(Tert-Butoxy)Carbonyl D-Glu(OMe)-OMe (Isiraphu);
I-Boc-D-Glu(OMe)-OMe (Isiraphu);
i-dimethyl (2R) -2- [(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate;
Ukungacoceki kweAlogliptin 43;
1,5-dimethyl (2R) -2-{[(tert-butoxy)carbonyl]amino}pentanedioate

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Usetyenziso

I-Fluoroquinolones ine-antibacterial spectrum ebanzi, umsebenzi oqinileyo wokulwa ne-antibacterial, ukusabela okuphantsi okungalunganga, ukunyanzeliswa kwezicubu ezilungileyo, i-bioavailability ephezulu yomlomo, ixesha elide lokulawula kunye nolawulo olufanelekileyo.Ngokuqhelekileyo zisetyenziswa kunyango lwezifo ezosulelayo ezifana nosulelo lwendlela yokuphefumla kunye nosulelo lwe-urinary tract.Ulwakhiwo lwe-fluoroquinolone antibacterial drug lubonakaliswa kubukho be-fluorine kwindawo yesithandathu yenucleus yomzali we-quinolone.
Nangona kunjalo, kwiminyaka yakutshanje ye-10, ngenxa yoxinzelelo olukhethiweyo oluveliswa kukusetyenziswa okubanzi kolu hlobo lwamachiza, iintlobo ezichasene neyeza zonyuka, ngakumbi kwiminyaka yakutshanje, i-quinolone-resistant Streptococcus pneumoniae inokumelana ne-cross-resistance, ekwazi ukumelana ne-penicillin, i-macrolide antibiotics kunye ne-quinolone antibiotics.Kwangaxeshanye, kwafunyaniswa ukuba ezinye fluoroquinolones kunokubangela QTc interval prolongation of electrocardiogram, hepatotoxicity kunye phototoxicity, nto leyo ukunciphisa ukusetyenziswa kwazo.
Ukuze woyise ezi ntsilelo zingentla ze-fluoroquinolones, kungxamisekile ukuba kuphuhliswe iikhompawundi ezintsha zesakhiwo ezinomsebenzi olungileyo wokulwa ne-antibacterial, i-antibacterial spectrum ebanzi kunye nencinci kangangoko kunokwenzeka iziphumo ezibi ngokuchasene neebhaktheriya ezichasene neziyobisi ezininzi.Uthotho lwamachiza amatsha e-fluoroquinolone-free (NFQ) asandul’ ukuphuhliswa aqulathe i-8-methoxyl ahlukile kwi-antibiotics ye-fluoroquinolone kuba ayinayo i-fluorine kwindawo yesi-6 ye-nucleus yomzali we-quinolone, kodwa isenamandla kwi-vitro antibacterial activity.I-nemonoxacin yi-NFQ entsha ekhethiweyo yebhaktiriya ye-topoisomerase inhibitor.
Xa kuthelekiswa ne-fluoroquinolones ekhoyo ngoku kwimarike, i-Nenofloxacin imele udidi olutsha lwamachiza esakhiwo.I-nemonocacin (TG-873870), ichiza elitsha le-quinolone eliphuhliswe yi-Procter & Gamble (P&G), libonise umsebenzi obalulekileyo wokulwa ne-antibacterial ngokuchasene neentlobo zeentsholongwane ezichaphazelekayo zonyango, ezibandakanya i-Staphylococcus aureus kunye ne-multidrug-resistant Streptococcus pneumoniae.Iziphumo zovavanyo kwiimpuku ezosulelekileyo zibonise ukuba impembelelo ye-antibacterial yale mveliso yomelele kuneyona quinolones yangoku.Ukongeza, imveliso ineempawu ezintle kakhulu ze-pharmacokinetic kwaye inyamezeleke kakuhle.

iimveliso ezinxulumene

Fmoc-Gly-glu(otbu)-oh	I-Boc-D-Glu(OBzl)-Oet
HL-Glu-OH	I-Boc-D-Glu(Obzl)-OH
I-HD-Glu-OH	I-Boc-D-Glu(Ome)-OH
I-DL-Glu-OH	I-Boc-D-Glu(Ome)-OH.DCHA
I-DL-Glu-OH.H2O	I-Boc-Glu(OBzl)-Obzl
L-Glu(Obzl)-NCA	I-Boc-L-Glu-OBzl
D-Glu(Obzl)-NCA	I-Boc-D-Glu-Obzl
I-DL-Glu (Obzl)-NCA	I-Boc-D-Glu-Otbu-OH
L-Glu-Obzl	Boc-D-Glu(OMe)-OMe
Tos-Glu-Obzl	I-Boc-D-Glu(Obzl)-Obzl
L-Glu(Ome)-Obzl.TOS	Boc-L-Glu(Ome)-Ome
I-AC-Glu(OtBu)	I-Boc-L-Glu(OMe)-OH
I-DL-Glu(Ome)	I-Boc-L-Glu(OBzl)-OH
I-HD-Glu (OMe)-OH	Boc-Glu-Otbu
HL-Glu(OMe)-OH	Boc-L-Glu(Obzl)-Ome
I-L-Glu(Obzl)	I-Boc-L-Glu(Oet)
I-HL-Glu(OtBu)-OH	Fmoc-L-Glu-OH
HL-Glu(OEt)-OH	Fmoc-D-Glu-OH
L-Glu(Otbu)-Otbu-OH	Fmoc-D-Glu(Ome)-OH
I-HD-Glu (OBzl)-OH	Fmoc-L-Glu(OcHx)-OH
D-Glu-OBzl	Fmoc-L-Glu(OMe)-OH
HL-Glu(Ome)-Otbu.Hcl	Fmoc-L-Glu(OtBu)-OH
D-Glu(Obzl)-Otbu.HCL	I-Fmoc-D-Glu(OBzl)-OH
D-Glu(OtBu)-OtBu•HCl	Fmoc-D-Glu(Otbu)-OH
L-Glu(OcHx) .hcl	Fmoc-L-Glu-OtBu
I-HL-Glu(OBzl)-OBzl.HCl	I-Fmoc-L-Glu(OBzl)-OH
HL-Glu-OBzl.HCl	Fmoc-L-Glu(Cbz-ewe)
D-Glu(OBzl)-OBzl.HCl	Fmoc-N-Me-L-Glu(Otbu)-OH
DL-Glu(Ome)-Ome.Hcl	Fmoc-glu-obzl
I-HL-Glu(OtBu)-OtBu•HCl	Cbz-L-Glu-OH
HL-Glu(OMe)-OMe.HCl	Cbz-D-Glu-OH
L-Glu(Obzl)-OME.HCL	ZL-Glu-OBzl
HL-Glu(OEt)-OEt·HCl	ZD-Glu-OBzl
L-Glu(Obzl)-Otbu.HCl	Cbz-L-Glu-Otbu
HD-Glu(OMe)-OMe·HCl	Cbz-D-Glu(ome)
N-Pht-Glu	Cbz-L-Glu(OBzl)-OH
I-Boc-L-Glu-OH	Cbz-L-Glu(Otbu)
I-Boc-D-Glu-OH	Cbz-L-Glu(Ome)
I-Boc-Glu(obzl)-NH2	Cbz-D-Glu(OtBu)-OH
I-Boc-Glu(trt)-OH	Cbz-L-Glu(Ome)-OtBu
I-Boc-L-Glu(OcHx)-OH	Cbz-L-Glu-OBzl.DCHA
I-Boc-L-Glu(OtBu)-OH	Cbz-L-Glu(Oet)-OH
Boc-Glu(Osu)-Otbu	Boc-Glu-Otbu (Osu)

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
I-3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina