China 15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH Umenzi kunye neFactory |Jiayinglai

15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Inkcazelo emfutshane:

Imbonakalo	Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale.
MF	C16H23NO5
MW	309.36
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, ubushushu beGumbi

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

Izithethantonye

I-Boc-O-Benzyl-L-threonine;
I-BOC-THR-OH;
I-BOC-THR(BZL)-OH;
iButoxacarbonylbenzylthreonine;
NT-boc-O-benzyl-L-threonine*crystalline;
I-O-benzyl-N-tert-butoxycarbonyl-L-threonine;
N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE;
I-NALPHA-tert-Butoxycarbonyl-O-benzyl-L-threonine

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Usetyenziso

Umgubo omhlophe wekristale;Ayinyibiliki emanzini nakwi-petroleum ether, i-ethyl acetate kunye ne-methanol;mp yi 115-116℃;Ukujikeleza okuthe ngqo [α] 20D + 15.8 ° (0.5-2.0 mg / ml, methanol).
Isetyenziselwa i-polypeptide synthesis, njenge-monomer yokukhusela i-amino acid.
I-O-benzyl-l-threonine yanqunyanyiswa kwisisombululo se-dioxane kunye ne-acylated kunye ne-tert-butylcarbonyl azide ukufumana imveliso ekrwada, ekhutshwe yi-ethyl acetate kwi-pH ye-9-10 kwaye iphinda iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde ihlaziywe.
Inxalenye esebenzayo ye-thymic oietin Ⅱ ye-thymus secretions.I-Thymoietin II yikhompawundi enye ye-polypeptide ekwahlulwa kwihomoni ye-thymus.Iqulethwe ngama-amino acid angama-49, kunye neqhekeza lekhonkco le-peptide elenziwe nge-5 amino acids linemisebenzi efanayo ye-physiological njenge-thymoietin II.Ke ngoko, esi siqwenga sepentapeptide sibizwa ngokuba yi-thymus pentapeptide.Umkhenkce omhlophe owomileyo okhululekileyo okanye umgubo.
Enye yeendima ze-thymus pentapeptide kukukhuthaza ukwahlula kweeseli ze-T.Inokukhetha ngokukhetha ukuguqulwa kweeseli ze-Thy-1-prothorax kwiiseli ze-Thy-1+ T.Ukwahlula kweeseli ze-T kulungelelaniswa ngokunyuka kwamanqanaba e-intracellular cAMP.Omnye umsebenzi osisiseko we-thymus pentapeptides kukubophelela kwii-receptors ezithile zeeseli zegazi ezivuthiweyo ze-T, ukwandisa inqanaba le-cAMP ye-intracellular, kwaye ngaloo ndlela kubangele uchungechunge lwe-intracellular reactions, ekwayisiseko somsebenzi wayo we-immunomodulatory.Kwimeko eqhelekileyo yomzimba, i-thymus pentapeptide ibonise i-immune stimulating effect, enokuthi inyuse kakhulu izinga le-E rosette yokwakheka kunye nesantya sokuguqulwa kwe-splenic lymphocytes, ukuphucula izigaba ezahlukeneyo zokuphendula okuphambili okanye okwesibini, kunye nokwandisa inani le-IgM kunye ne-IgG okanye Uhlobo lwe-IgA ye-antibody eyenza iiseli.I-Thymus pentapeptide inokwandisa umsebenzi we-phagocytosis ye-macrophages, ukwandisa i-enzyme kunye nomsebenzi we-phagocytosis we-polymorphonuclear neutrophils, ukwandisa umxholo we-antibody ojikelezayo, kunye nokuphucula umsebenzi wokuzivikela kwiiseli ezibomvu zegazi.I-Thymus pentapeptide ingenza i-CD4 kunye neeseli ze-CD8 zisebenze, ukwenzela ukuba iiseli ze-Tc ezithile zikwazi ukugcina ubomi obude, kodwa zinokuvula iiseli ze-T kwaye zenze umsebenzi weeseli ze-T.Iimpembelelo ezichasayo kunye nezonyango ze-thymus pentapeptide zinxulumene nokwandiswa kwayo kwemisebenzi yeseli ye-TC.Umlinganiselo ofanelekileyo we-thymus pentapeptide unokwandisa kakhulu ukuveliswa kwe-interferon kwi-anti-infection immunity.Ukukhuthaza kunye nokukhuthaza ukwahlula kweeseli T kunye nokuvuthwa;I-CD4/CD8 ithande ukuba yesiqhelo ngokulawula umyinge we-T lymphocyte subsets;Ukuphucula umsebenzi we-phagocytosis we-macrophages;Ukuphucula ukusebenza kwe-immune cell cell;Ukwandisa umsebenzi weeseli ezibulalayo zendalo;Ukwandisa inqanaba le-interleukin-2 yokuvelisa kunye nokubonakaliswa kwe-receptor;Ukuphucula ukuveliswa kwe-γ interferon kwi-peripheral blood mononuclear cells;Ukuphucula umsebenzi weSOD kwiserum.
Ingasetyenziswa kwizigulana zethumba eliyingozi ezinokukhubazeka kokusebenza komzimba emva kweradiotherapy kunye nechemotherapy.Unyango lwe-hepatitis B;Utyando olukhulu kunye nosulelo olunzima;izifo ezizimelayo ezifana ne-rheumatoid arthritis, lupus erythematosus;Uhlobo lwe-II yesifo sikashukela, i-menopause syndrome;Umntu onomzimba obuthathaka.

iimveliso ezinxulumene

Fmoc-L-Thr(tBu)-Phe-OH	Boc-D-Thr-OH
HL-Thr-OH	Boc-D-Thr(me)-OH
I-DL-Thr	I-Boc-D-Thr(Bzl)-OH
HL-allo-Thr-OH	Cbz-Thr-OH
L-Thr(bzl)	Cbz-Thr-Obzl
HL-Thr(tBu)-OH	ZL-Thr-ome
L-Thr(mna)	Cbz-D-Thr-OH
Thr-Otbu.hcl	Cbz-L-Thr(tBu)-OH
L-Thr(bzl).HCl	Cbz-L-Thr(bzl)-OH
L-Thr(me).Hcl	Cbz-L-Thr(tBu)-OH DCHA
L-Thr-Obzl.HCl	Fmoc-L-Thr-OH
HL-Thr-OMe.HCl	fmoc-L-Thr-OtBu
L-Thr-Oet.Hcl	Fmoc-L-Thr-Obzl
L-Allo-Thr-Ome.Hcl	Fmoc-L-Allo-Thr-OH
HL-Thr-OBzl · oxalate	Fmoc-Thr(tBu)-OH
D-Thr(bzl).HCl	Fmoc-L-Thr(bzl)-OH
D-Thr-Oet.Hcl	Fmoc-D-Thr-OH
D-Thr-Obzl.HCl	Fmoc-D-Thr(bzl)-OH
D-Thr-Ome.HCl	Fmoc-D-Thr(tBu)-OH
I-DL-Thr-Ome.HCl	Fmoc-L-Thr(tBu)-Ser-OH
Boc-L-Thr-OtBu	Boc-n-me-l-thr(bzl).CHA
Boc-L-Thr-OH	Fmoc-N-Me-L-Thr(bzl)-OH
Boc-L-allo-Thr-OH	Fmoc-L-Thr(tBu)-Gly-OH
Boc-Thr-OMe	(2S,3S)-2-Amino-3-methoxybutanoic acid/L-AlloThr(Me)
Boc-Thr-Obzl	(2S,3S)-2-Amino-3-methoxybutanoic acid/BOC-AlloThr(Me)
I-Boc-L-Thr(tBu)-OH	HL-Thr(Bzl)-OBzl.oxalate
I-Boc-L-Thr(Bzl)-OH	Boc-D-Thr-Ome
Boc-L-Thr(me)-OH

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
I-3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina