15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Umgubo omhlophe wekristale;Ayinyibiliki emanzini nakwi-petroleum ether, i-ethyl acetate kunye ne-methanol;mp yi 115-116℃;Ukujikeleza okuthe ngqo [α] 20D + 15.8 ° (0.5-2.0 mg / ml, methanol).
Isetyenziselwa i-polypeptide synthesis, njenge-monomer yokukhusela i-amino acid.
I-O-benzyl-l-threonine yanqunyanyiswa kwisisombululo se-dioxane kunye ne-acylated kunye ne-tert-butylcarbonyl azide ukufumana imveliso ekrwada, ekhutshwe yi-ethyl acetate kwi-pH ye-9-10 kwaye iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde ihlaziywe.
Inxalenye esebenzayo ye-thymic oietin Ⅱ ye-thymus secretions.I-Thymoietin II yikhompawundi enye ye-polypeptide ekwahlulwa kwihomoni ye-thymus.Iqulethwe ngama-amino acid angama-49, kunye neqhekeza lekhonkco le-peptide elenziwe nge-5 amino acids linemisebenzi efanayo ye-physiological njenge-thymoietin II.Ke ngoko, esi siqwenga sepentapeptide sibizwa ngokuba yi-thymus pentapeptide.Umkhenkce omhlophe owomileyo okhululekileyo okanye umgubo.
Enye yeendima ze-thymus pentapeptide kukukhuthaza ukwahlula kweeseli ze-T.Inokukhetha ngokukhetha ukuguqulwa kweeseli ze-Thy-1-prothorax kwiiseli ze-Thy-1+ T.Ukwahlula kweeseli ze-T kulungelelaniswa ngokunyuka kwamanqanaba e-intracellular cAMP.Omnye umsebenzi osisiseko we-thymus pentapeptides kukubophelela kwii-receptors ezithile zeeseli zegazi ezivuthiweyo ze-T, ukwandisa inqanaba le-cAMP ye-intracellular, kwaye ngaloo ndlela kubangele uchungechunge lwe-intracellular reactions, ekwayisiseko somsebenzi wayo we-immunomodulatory.Kwimeko eqhelekileyo yomzimba, i-thymus pentapeptide ibonise i-immune stimulating effect, enokuthi inyuse kakhulu izinga le-E rosette yokwakheka kunye nesantya sokuguqulwa kwe-splenic lymphocytes, ukuphucula izigaba ezahlukeneyo zokuphendula okuphambili okanye okwesibini, kunye nokwandisa inani le-IgM kunye ne-IgG okanye Uhlobo lwe-IgA ye-antibody eyenza iiseli.I-Thymus pentapeptide inokwandisa umsebenzi we-phagocytosis ye-macrophages, ukwandisa i-enzyme kunye nomsebenzi we-phagocytosis we-polymorphonuclear neutrophils, ukwandisa umxholo we-antibody ojikelezayo, kunye nokuphucula umsebenzi wokuzivikela kwiiseli ezibomvu zegazi.I-Thymus pentapeptide ingenza i-CD4 kunye neeseli ze-CD8 zisebenze, ukuze iiseli ze-Tc ezithile zikwazi ukugcina ubomi obude, kodwa zinokuvula iiseli ze-T kwaye zenze umsebenzi weeseli ze-T.Iimpembelelo ezichasayo kunye nezonyango ze-thymus pentapeptide zinxulumene nokwandiswa kwayo kwemisebenzi yeseli ye-TC.Umlinganiselo ofanelekileyo we-thymus pentapeptide unokwandisa kakhulu ukuveliswa kwe-interferon kwi-anti-infection immunity.Ukukhuthaza kunye nokukhuthaza ukwahluka kweeseli ze-T kunye nokuvuthwa;I-CD4/CD8 ithande ukuba yesiqhelo ngokulawula umyinge we-T lymphocyte subsets;Ukuphucula umsebenzi we-phagocytosis we-macrophages;Ukuphucula ukusebenza kwe-immune cell cell;Ukwandisa umsebenzi weeseli ezibulalayo zendalo;Ukwandisa inqanaba le-interleukin-2 yokuvelisa kunye nokubonakaliswa kwe-receptor;Ukuphucula ukuveliswa kwe-γ interferon kwi-peripheral blood mononuclear cells;Ukuphucula umsebenzi weSOD kwiserum.
Ingasetyenziswa kwizigulana zethumba eliyingozi ezinokukhubazeka kokusebenza komzimba emva kweradiotherapy kunye nechemotherapy.Unyango lwe-hepatitis B;Utyando olukhulu kunye nosulelo olunzima;izifo ezizimelayo ezifana ne-rheumatoid arthritis, lupus erythematosus;Uhlobo lwe-II yesifo sikashukela, i-menopause syndrome;Umntu onomzimba obuthathaka.