I-China 53267-93-9 Tert-butoxycarbonyl-L-Tyrosine(methyl)-OH uMvelisi kunye neFactory |Jiayinglai

53267-93-9 Tert-butoxycarbonyl-L-Tyrosine(methyl)-OH

Inkcazelo emfutshane:

Imbonakalo	Iikristale eziMhlophe ukuya kwi-Off-White okanye umgubo wekristale.
MF	C15H21NO5
MW	295.33
Ubunyulu	98+

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Imeko yezothutho&ecetyiswayo indlela yokuthumela ngenqanawa:
ngomoya, ngolwandle okanye nge-express

Imeko yokugcina:
Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi

Ubuncinci boMyinge woMyalelo:
Uthethathethwano

Isiqinisekiso:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC iyafumaneka

Izithethantonye

I-Boc-O-methyl-L-tyrosine;
I-BOC-O-METHYL-L-TYROSINE;
I-BOC-PHE(4-OME)-OH;BOC-P-METHOXY-PHE-OH;
BOC-L-TYR(ME);
I-BOC-L-4-METHOXYPHE;
I-BOC-4-METHOXYPHENYLALANINE;
BOC-4-METHOXY-PHE-OH

Ukupakishwa kwangaphakathi

Ngokuqhelekileyo zisetyenziselwa ukupakisha umgubo.Yaye anokuthintela ukukhanya kwelanga namanzi ukuba angabi mabi.

ukupakisha kwangaphandle

Ibhokisi elukhuni inokukhusela iimveliso zakho ekuqhekekeni kwaye zibe manzi.

Usetyenziso

Ikhadi i-bei oxytocin (i-Carbetocin) luhlobo lwe-synthesis yokusebenza ixesha elide kunye neempawu ze-agonist i-oxytocin 8 umxholo we-peptide, iimpawu zayo zeklinikhi kunye ne-pharmacological ezifana nokuvelisa i-oxytocin yendalo.Njenge-oxytocin, i-cabetin ibophelela kwi-oxytocin receptors kwi-muscle egudileyo yesibeleko, ibangela ukuthotywa kwe-rhythmic yesibeleko, ukwandisa ukuphindaphinda kwayo kunye nokwandisa ukuxinana kwesibeleko phezu kwe-contraction yokuqala.Amanqanaba e-oxytocin receptors kwi-uterus aphantsi ngexesha lokungabikho kokukhulelwa kwaye ayanda ngexesha lokukhulelwa, ukunyuka ekuzalweni.Ngoko ke, i-cabetin ayinayo impembelelo kwi-uterus engakhulelwe, kodwa ine-contraction ye-uterine esebenzayo kwi-uterus ekhulelweyo kunye nesibeleko emva kokuzalwa.I-intravenously okanye ngaphakathi, i-uterus inkontileka ngokukhawuleza, ifikelela kumandla aqinisekileyo ngaphakathi kwemizuzu emi-2.Idosi enye ye-capetin elawulwa ngomthambo iyasebenza kwisibeleko malunga neyure enye, eyaneleyo ukuthintela ukopha kwasemva kokubeleka ngoko nangoko emva kokunikezelwa.I-frequency kunye ne-amplitude ye-contractions emva kokulawulwa kwe-postpartum ye-carpetin yayinde kune-oxytocin.Uphononongo lubonise ukuba xa unikwe idosi enye ye-100μg nge-intravenously ngokukhawuleza emva kwecandelo lotyando phantsi kwe-epidural okanye i-lumbar anesthesia, i-carbetin iphezulu kakhulu kune-placebo ekukhuseleni i-hypotonia yesibeleko kunye nokunciphisa ukuphuma kwegazi emva kokubeleka.I-Carpeine enikwe ngexesha lokuqala lokubeleka inokukhuthaza ukubuyiswa kwesibeleko.
I-Cabetin ibophelela kwi-oxytocin receptors kwisihlunu esigudileyo sesibeleko ukuze ibangele ukuba isibeleko sifinyezeke ngesingqi, sinyuse amaxesha ayo okufinyela kunye nokwandisa ukutsaleka kwesibeleko.Idosi enye ye-carbetin inokunikwa ngokukhawuleza emva kokuzalwa komntwana ukuthintela ukopha kwasemva kokubeleka.Kuye kwafunyaniswa ukuba i-postpartum intravenous injection ye-oxytocin idibene nokulawulwa kwe-cabetin inokuthintela ngokufanelekileyo ukulahleka kwegazi emva kokubeleka.Emva kwecandelo lotyando, ukusetyenziswa kwe-cabetin edibeneyo ne-oxytocin kunokomeleza ukuchithwa kwe-uterine, ukunciphisa ukulahlekelwa kwegazi emva kwecandelo lotyando, umphumo ungcono ngakumbi kune-hemabate.Kwabasetyhini abane-cicatritic uterus, i-placenta previa kunye nezinye izinto ezinobungozi obuphezulu bokuphuma kwegazi emva kokubeleka, i-carbetin inokuthintela ngokufanelekileyo ukwenzeka kwe-postpartum hemorrhage.Isetyenziselwa i-epidural ekhethiweyo okanye i-anesthesia ye-lumbar emva kwecandelo le-cesarean ukukhusela ubuthathaka be-uterine contraction kunye ne-postpartum hemorrhage.

iimveliso ezinxulumene

Boc-Gly-Tyr-OH	Boc-L-Tyr-Obzl	L-Tyr(mna)	Cbz-L-Tyr-OH
Boc-Gly-Tyr-OMe	I-Boc-L-Tyr(tBu)-OH	L-Tyr(mna).Hcl	Cbz-D-Tyr-OH
Gly-L-Tyr-OH	Boc-Tyr(bzl)-OH	D-Tyr(bzl).Hcl	Cbz-N-Me-Tyr(tbu)-OH
Gly-L-Tyr-OH	Boc-D-Tyr(bzl)-OH	D-Tyr(Et).HCl	cbz-L-Tyr-Ome
Fmoc-β-Ala-D-Tyr (Et)	Boc-L-Tyr(mna)-OH	L-Tyr(bzl)-obzl.Hcl	Cbz-L-Tyr(Et)-OH
Val-Tyr-OH	Boc-D-Tyr(mna)-OH	L-Tyr(tbu)-OH	Z-Tyr(tbu)
Cbz-L-Val-Tyr-OH	Boc-Tyr (kodwa).Aib	L-Tyr-OL.Hcl	Z-Tyr(bzl)-OH
Cbz-L-Val-Tyr-Ome	Fmoc-L-Tyr-OH	D-Tyr-Ome.Hcl	Z-Tyr(tbu).DCHA
Ile-Tyr	Fmoc-N-Me-Tyr(tBu)-OH	L-Tyr(bzl)-Ome.Hcl	Tyr-Phe
Boc-Ile-Tyr	FMOC-N-Me-D-Tyr(me)-OH	L-Tyr-Oet-OH	Tyr-Asp
Tyr-Pro-Otbu	Fmoc-N-Me-D-Tyr(tBu)-OH	D-Tyr-Oet•HCl	Arg-Tyr-Oet
L-Phe-Tyr-OH	Fmoc-N-Me-L-Tyr(bzl)-OH	L-Tyr-Ome.HCl	Cbz-L-Ser-Tyr
Boc-L-Phe-Tyr-OH	Fmoc-L-Tyr-Ome	HL-Tyr-Oet.Hcl	Tyr(bzl)-obzl
L-Tyr-OH	Fmoc-L-Tyr(Cbz)	Ac-D,L-Tyr-OH	Boc-N-Me-D-Tyr(bzl)-OH
D-Tyr-OH	Fmoc-L-Tyr(bzl)-oh	AC-L-Tyr-OH	Boc-N-Me-L-Tyr(tbu)-OH
DL-Tyr	Fmoc-L-Tyr(Et)-OH	N-Ac-L-Tyr-Oet	Boc-L-Tyr-OL
N-Me-Tyr(mna)-OH	Fmoc-L-Tyr(tBu)-OH	L-Tyr-Otbu	Boc-D-Tyr(bzl)-OL
N-Me-Tyr(mna).HCL	Fmoc-L-Tyr(mna)	D-Tyr-Otbu	Boc-L-Tyr(bzl)-Ol
L-Tyr-NCA	Fmoc-L-Tyr(mna)-tyr(mna)	L-Tyr-Obzl	Boc-L-Tyr(me)-OL
D-Tyr-NCA	Fmoc-D-Tyr(mna)-OH	L-Tyr-obzl-Tos-OH	Boc-Tyr(Et).OL
Tyr(bzl)-NCA	Fmoc-D-Tyr(Et)-OH	Boc-L-Tyr-OH	Boc-L-Tyr-Ome
Tyr(bzl)-NCA	Fmoc-D-Tyr(Et)-D-Tyr(Et)	Boc-D-Tyr-OH	Boc-D-Tyr-Ome
L-Tyr(Et)-OH	Fmoc-D-Tyr(tbu)-OH	Boc-DL-Tyr-OH	Boc-Tyr-Otbu
Boc-L-Tyr(Et)-OH	Boc-DL-Tyr-Otbu	Boc-L-Tyr-Oet	Boc-D-Tyr-Otbu
Boc-D-Tyr(Et)-OH	Boc-N-Me-L-Tyr(bzl)-OH

Ukongama

1. Inkonzo yeR&D iyafumaneka
2. Umvelisi oqinisekisiweyo we-ISO, isiqinisekiso somgangatho
I-3.Ikhosi epheleleyo yenkonzo yokulandelela ngexesha lemveliso
4.Ixabiso eliphezulu elisebenzayo
5.Amaxwebhu esiqinisekiso somgangatho anikwe ngokwesicelo somthengi
I-6.Inkonzo enkulu emva kokuthengisa, ukugcina ubudlelwane obusondeleyo kunye nomthengi
I-7.Isixhobo esipheleleyo sokunceda ukunciphisa iindleko zokuthumela ngenqanawa
I-8.Isampuli yamahhala enikezelwa ukujonga umgangatho ngaphambi kwayo nayiphi na intlawulo
9.Ixesha lentlawulo ekuxoxwe ngalo
Abathengi be-10.Assit bajongana nemicimbi yaseTshayina