87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE

Le mveliso i-polypeptide eyenziwe ngama-amino acids angama-28.Kuba N - acetyl - L - isilika ammonia acyl - L - alpha amino ammonia acyl - L - propylene ammonia acyl - L - propylene ammonia acyl - L - valerian ammonia acyl - L - alpha amino ammonia acyl - L - Sue ammonia acyl - L - wire ammonia acyl - L - wire ammonia acyl - L - alpha glutamine - L - ezahlukeneyo ukukhanya ammonia acyl - L - Sue ammonia acyl - L - Sue ammonia acyl - L - lai ammonia acyl - L - alpha amino ammonia acyl - L - ammonia ekhanyayo acyl - L - lai ammonia acyl - L - alpha - glutamine - L - lai ammonia acyl - L - lai ammonia acyl - L - alpha glutamine - L - valerian ammonia acyl - L - valerian ammonia acyl - L - alpha glutamine - L - alpha - glutamine - L - propylene ammonia iwayini - L - alpha - glutamine - L - asparagine.Ngokwezibalo ze-anhydrous kunye ne-acetic acid-free substance, i-thymus equkethe indlela (C129 H215 N33O55) kufuneka ibe yi-95.0% ~ 105.0%.
Le mveliso ngumgubo omhlophe okanye omhlophe okanye ubunzima obunzima.
Le mveliso inyibilika kwi-trifluoroacetic acid, i-soluble kancinci emanzini, ayinyibiliki kwi-acetonitrile, ether kunye ne-trichloromethane.
Thatha le mveliso, ulinganise ngokuchanekileyo, yongeza i-0.02mol / L isisombululo se-phosphate buffer (pH 7.0) (thatha i-2.72g ye-potassium dihydrogen phosphate, yongeza i-0.1mol / L isisombululo se-sodium hydroxide 116.4ml ukuchithwa, ukuhlambulula ngamanzi kwi-1000ml) kwaye wenze isisombululo esiqulethe malunga ne-5mg kwi-1ml nganye.Ngokumiselwa ngokomthetho (Isihlomelo ⅥE seCandelo II le-Pharmacopoeia, uhlelo luka-2010), i-curl ethile kufuneka ibe ngu-100.0 ° ukuya -110.0 ° ngokusekelwe ekubalweni kwezinto ezingenayo i-anhydrous kunye ne-acetic-free.
Indlela yokusebenza yale mveliso ekuphatheni i-hepatitis B engapheliyo kunye nokuphucula i-immune system reactivity ayizange icaciswe ngokupheleleyo.Uninzi lweemvavanyo ze-in vitro lubonise ukuba le mveliso inokukhuthaza ukuvuthwa kwe-T lymphocytes ngokuvuselela i-mitogen ye-lymphocytes yegazi ye-peripheral, ukwandisa amanqanaba e-interferon α, i-interferon γ, i-interleukin 2, i-interleukin 3 kunye nezinye izinto ze-lymphatic ezifihliweyo kwiiseli ze-T. emva kokusebenza kwe-antigen okanye i-mitogen, kwaye ngexesha elifanayo ukwandisa izinga le-lymphofactor receptors kumphezulu weeseli ze-T.Isenokuphucula impendulo ye-allogeneic kunye ne-autologous human lymphocytes exutywe ngokusebenza kweeseli ze-CD4.Le mveliso inokunyusa ukuhlanganiswa kweeseli zangaphambi kwe-NK, kwaye i-interferon inokunyusa i-cytotoxicity.Iimvavanyo ze-vivo zibonise ukuba le mveliso inokunyusa izinga lokubonakaliswa kwe-interleukin-2 receptor kunye nenqanaba le-secretion ye-interleukin-2 kwi-lymphocytes ye-mouse emva kwe-cancanadin A activation.