22254-24-6 8-Isopropylatropinium bromide

I-Ipratropium bromide yaziwa nangokuthi yi-Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, kunye ne-ipratropium bromide.Ingumgubo omhlophe wekristale onencasa ekrakra.Indawo yokunyibilika 232℃-233℃.Inyibilika emanzini, inyibilika kancinane kwi-ethanol, ayinyibiliki kwezinye izinyibilikisi zendalo.Igama leKhemikhali: I-Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Lichiza le-anticholinergic, elinesiphumo esinamandla sokuphumla kwi-bronchial smooth muscle kunye ne-antiasthmatic effect kwi-chronic obstructive pulmonary disease.Umphumo wayo ucacile, umphumo okhawulezayo kunye nexesha elide.I-Ipratropium bromide iphinda ilawule ukukhuselwa kweengqungquthela ze-mucus kunye nokuphucula ukunyakaza kwe-ciliary, ngaloo ndlela kuncitshiswe ukuvinjelwa kwe-sputum ukuphucula umoya.Ngeli xesha, ukuncitshiswa kwesikhohlela kwakhona kunciphisa i-bronchospasm ebangelwa ukucaphuka kwe-bronchial.Ukuthintela kunye nokunyangwa kwe-asthma ye-bronchial kunye ne-asthmatic chronic bronchitis, ngakumbi kwizigulane ezingakwazi ukunyamezela ukusetyenziswa kwe-β-agonist muscle tremor, tachycardia.Le mveliso ingasetyenziselwa ukudibanisa kunye ne-beta-agonists ukuphucula ukusebenza komnye nomnye, njengokudibanisa ne-finoterol ukwenza i-aerosol (BERODU - AL) ye-asthma, i-bronchitis engapheliyo kunye ne-emphysema.Xa kuthelekiswa ne-β-adrenergic receptor stimulants (umzekelo, isopropyl epinephrine), le mveliso ineziphumo ebezingalindelekanga ezincinci ze-cardiovascular, kwaye xa kuthelekiswa ne-β2-receptor stimulants (umzekelo, i-Suquanling), le mveliso inefuthe elinamandla lokulawula umthamo wephlegm.
Tshaza ukuphefumla.40 ~ 80μg kanye, 2 ~ 4 amaxesha ngosuku.Xa usebenzisa, qala ngokususa iqokobhe leqweqwe lekhava, beka iqokobhe leqokobhe elinqamlezileyo emlonyeni, ujike ibhotile uyijonge phantsi, qulathe iqokobhe lokugquma emlonyeni, jolise emqaleni, funxa irhasi ngaxeshanye, cinezela umlomo. kwivalve, phefumlela ulwelo, ubambe umoya wakho okomzuzwana.Phinda oku ngasentla kube kanye ukuba kuyimfuneko.I-aerosol: isisombululo se-0.025%.Icwecwe: 10mg/tablet.
Ityhefu enkulu ye-anticholinergic inokunyangwa nge-cholinesterase inhibitors.
Ukuphendula okungathandekiyo kwe-ipratropium bromide kufana ne-atropine, enokubangela ukubetha kwentliziyo, intloko ebuhlungu, isiyezi, uvalo, isicaphucaphu, ukugabha, iintlungu zesisu, ukungcangcazela, ukungaboni kakuhle, umlomo owomileyo, ukukhohlela, idysuria, ukwanda kweempawu zokuphefumla kunye nerhashalala.
I-Ipratropium bromide ngumchasi we-muscarinic, i-bronchodilator, kunye netyuwa ye-isopropyl ye-AtropineN.
I-Ipratropiumbromide kunye ne-Formoterol zidibene ngokuyinxenye ukukhusela imiphunga ekudumbeni okungapheliyo kunye nokwandisa imiphunga, ukunciphisa i-neutrophils ngokuvimbela umsebenzi nge-MMP-9.I-Ipratropiumbromide (1nM) yandisa kakhulu i-calcium bromide, yanciphisa ukusabalalisa phambili kunye nokunyuka kwe-annexin-V yokubopha.Emva konyango lwe-Ipratropiumbromide, i-hemolysis yanda kancinci kodwa kakhulu.I-Ipratropiumbromide ibangela ukuzibulala kweeseli ezibomvu zegazi okanye i-eryptosis, ngokuyintloko ngenxa yokuvuselela i-calcium.
I-Ipratropium i-powder dry inhalation (DPI) yayiyi-bronchodilator esebenzayo ekuphumleni amahashe kwi-dose ye-2400 mg / ihashe, kunye nefuthe elincinci kwi-airway caliber ephezulu ngexesha lokubuyisela.Kwiimpuku eziphathwe nge-cadmium, i-Ipratropium yanciphisa kakhulu ukungena kweseli ye-parenchymal yokuvuvukala kwaye yabona izilonda ezixineneyo zemiphunga.I-Ipratropium ikhusela ngokuyinxenye imiphunga ekudumbeni ngokunciphisa ukungena kwe-neutrophil.Kwi-guinea pig tracheal muscle smooth, i-Ipratropium ngumchasi othintela i-prebound muscarinic inhibitory receptor ye-lung parasympathetic nerve.I-Ipratropium nayo ibonakaliswe ukuba ngumchasi onamandla emva kokubopha kwi-muscarinic inhibitory receptors.I-Ipratropium inciphisa utshintsho oluphezulu kwixinzelelo lwesifuba kwaye inyuse ukuthotyelwa okuguquguqukayo (i-Cdyn) ekuphefumuleni kwamanzi (i-Pplmax eyongezelelweyo) kunye nokumelana nemiphunga (RL) kumahashe.